期刊论文详细信息
Diagnostic Pathology
A case report of Indium lung with progressive emphysema and fibrosis underwent lung unilateral transplantation 20 years after the end of the exposure
Case Report
Takashi Suzuki1  Chihiro Inoue1  Atsuko Amata2  Tatsuya Chonan2  Shinya Ohkouchi3  Hajime Kurosawa3  Ryoko Saito-Koyama4  Takashi Hirama5  Yoshinori Okada5  Yoshinori Kawabata6  Akiyo Tanaka7 
[1] Department of Anatomic Pathology, Graduate School of Medicine, Tohoku University, Sendai, Japan;Department of Medicine, Nikko Memorial Hospital, Hitachi, Japan;Department of Occupational Health, Graduate School of Medicine, Tohoku University, Sendai, Japan;Department of Pathology, National Hospital Organization, Sendai Medical Center, Sendai, Japan;Department of Thoracic Surgery, Institute of Development, Aging and Cancer, Tohoku University, Sendai, Japan;Division of Diagnostic Pathology, Saitama Prefectural Cardiovascular and Respiratory Center, Kumagaya, Japan;Environmental Medicine, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan;
关键词: Case report;    Indium lung;    Transplantation;    Emphysema;    Fibrosis;   
DOI  :  10.1186/s13000-023-01303-1
 received in 2022-12-21, accepted in 2023-01-23,  发布年份 2023
来源: Springer
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【 摘 要 】

BackgroundIndium lung is characterized by interstitial pneumonia and/or emphysema which occurs in indium-tin oxide (ITO) workers. Indium lung is now known to progress after stopping exposure to ITO, but the long-term influences of ITO remain unclear.Case presentationForty seven years old, a never-smoker, who had been engaged in an ITO manufacturing process for 8 years. Emphysema was indicated by the medical check-up for ex-ITO workers, and he was diagnosed with indium lung. He underwent partial lung resections for pneumothorax two times, and obstructive pulmonary dysfunction had progressed through the years. He underwent right single lung transplant 20 years after ITO exposure. Pathologically, his lung showed severe distal acinar emphysema and honeycomb change. Fibrosis and destruction of the lung tissue significantly progressed compared to the previous partial resections. Scanning electron microscopy combined with energy dispersive spectroscopy revealed that the deposited particles contained indium and tin. After the transplantation, his respiratory function was improved.ConclusionsIn this case, ITO resided in the lung tissue for 20 years, and lung tissue destruction kept progressing. Careful medical follow-up is recommended for ITO-workers even if they are asymptomatic.

【 授权许可】

CC BY   
© The Author(s) 2023

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