Prospective association between phthalate exposure in childhood and liver function in adolescence: the Ewha Birth and Growth Cohort Study

Environmental Health

Research

Hye Ah Lee¹  Young Sun Hong²  Eun Hee Ha³  Seonhwa Lee⁴  Hyejin Han⁵  Hyesook Park⁶  Bohyun Park⁷ 

[1] Clinical Trial Center, Ewha Womans University Mokdong Hospital, 07985, Seoul, Korea;Department of Internal Medicine, College of Medicine, Ewha Womans University, 07804, Seoul, Korea;Department of Occupational and Environmental Medicine, College of Medicine, Ewha Womans University, 07804, Seoul, Korea;Graduate Program in System Health Science and Engineering, Ewha Womans University, 07804, Seoul, Korea;Department of Preventive Medicine, College of Medicine, Ewha Womans University, 07804, Seoul, Korea;Center of Public Healthcare, National Medical Center, 04564, Seoul, Korea;Department of Preventive Medicine, College of Medicine, Ewha Womans University, 07804, Seoul, Korea;Gangdong Public Healthcare Center, 05397, Seoul, Korea;Department of Preventive Medicine, College of Medicine, Ewha Womans University, 07804, Seoul, Korea;Graduate Program in System Health Science and Engineering, Ewha Womans University, 07804, Seoul, Korea;National Cancer Control Institute, National Cancer Center, 10408, Goyang, Korea;

关键词: Phthalates;    Liver function;    Children;    Cohort;    Interaction effect;   

DOI  :  10.1186/s12940-022-00953-w

 received in 2022-09-14, accepted in 2022-12-27,  发布年份 2022

来源: Springer

【 摘 要 】

BackgroundPhthalate exposure is ubiquitous due to the widespread use of plastic products in daily life, and affects several health outcomes, including metabolic diseases. In this study, we evaluated the effects of phthalate exposure in childhood on liver function in adolescence. MethodsAmong 164 Ewha Birth and Growth Cohort Study participants followed up during two exposure periods (when the children were aged 3–5 and 7–9 years), 126 were followed up at age 10–15 years. To investigate the relationship between phthalate exposure during the two periods and liver enzyme levels (ALT, AST, γ-GTP) in adolescence, differences between groups and the dose–response relationship were analyzed. In addition, we investigated differences in liver enzymes between groups based on the combined exposure levels (high or low) during the two periods. The interaction effect between phthalates and BMI on liver enzyme levels was evaluated, stratified by sex. ResultsIn the 3–5 year-old exposure period, ALT levels tended to increase as MECPP levels increased, while γ-GTP levels tended to increase as MiBP, MnBP, and ∑DBP levels increased. In addition, the group exposed to consistently high levels of phthalates at both time points had higher liver enzyme levels compared to the group that had lower exposure. In particular, the interaction effect between some phthalate metabolites and BMI in 3–5 year olds affected AST and γ-GTP levels in adolescence only in girls.ConclusionsExposure to phthalates in daily life during childhood affects liver enzyme levels in adolescence. Elevated liver enzyme levels are associated with the development of metabolic syndrome, implying that attention should be paid to phthalate exposure during childhood.

【 授权许可】

CC BY   
© The Author(s) 2023

【 图 表 】

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