Association between red blood cell folate and Trichomonas vaginalis infection among women

BMC Infectious Diseases

Research

Wan-Zhe Liao¹  Zi-Xun Wang¹  Zhi-Yi Zhou²  Xu-Guang Guo³  Jun-Hao Mao⁴  Yi-Ming Hu⁵  Qiao-Rui Zheng⁶  Yong-Fu Lou⁶ 

[1] Department of Clinical Laboratory Medicine, The Third Affiliated Hospital of Guangzhou Medical University, 510150, Guangzhou, China;Department of Clinical Medicine, The Nanshan College of Guangzhou Medical University, 511436, Guangzhou, China;Department of Clinical Laboratory Medicine, The Third Affiliated Hospital of Guangzhou Medical University, 510150, Guangzhou, China;Department of Clinical Medicine, The Third Clinical School of Guangzhou Medical University, 511436, Guangzhou, China;Department of Clinical Laboratory Medicine, The Third Affiliated Hospital of Guangzhou Medical University, 510150, Guangzhou, China;Guangdong Provincial Key Laboratory of Major Obstetric Diseases, The Third Affiliated Hospital of Guangzhou Medical University, 510150, Guangzhou, China;Guangzhou Key Laboratory for Clinical Rapid Diagnosis and Early Warning of Infectious Diseases, KingMed School of Laboratory Medicine, Guangzhou Medical University, Guangzhou, China;Department of Computer Science, Nanjing University of Posts and Telecommunications, 210023, Nanjing, China;Department of Electronic Information Engineering, Glasgow College, University of Electronic Science and Technology, 611731, Chengdu, China;Department of Thoracic Surgery, Shangrao People’s Hospital, Shangrao, China;

关键词: Trichomonas vaginalis;    RBC folate;    NHANES;    Multivariate regression models;    Gynecological disease;   

DOI  :  10.1186/s12879-022-07950-x

 received in 2022-08-11, accepted in 2022-12-16,  发布年份 2022

来源: Springer

【 摘 要 】

BackgroundIncreased folic acid has been found to be latently protective against gynecological infection, including several kinds of vaginosis. In this study, we laid emphasis on whether RBC (Red Blood Cell) folate was associated with the infectious ratio of Trichomonas vaginalis, a kind of anaerobic parasitic protozoan.MethodsWe set RBC folate as the exposure variable and Trichomonas vaginalis as the outcome variable. Other subsidiary variables were regarded as covariates that may work as potential effect modifiers. The cross-sectional study was conducted with two merged waves of the National Health and Nutrition Examination Survey (NHANES) from 2001 to 2004, and a sample of 1274 eligible women (1212 negative and 62 positive in Trichomonas vaginalis infection) was integrated for the exploration of the association between RBC folate and Trichomonas vaginalis infection. Multivariate regression analyses, subgroup analyses, and subsequent smooth curve fittings were conducted to estimate the relationship between RBC folate and Trichomonas vaginalis in women.ResultsIn the multivariable logistic regression analyses, a negative association was observed between stratified RBC folate status and Trichomonas vaginalis infection with all confounders adjusted. Referencing the lowest RBC folate concentration quartile, the higher concentration quartiles reported a relatively lower infection ratio, while there was a weak correlation between total RBC folate concentration and T. vaginalis (Trichomonas vaginalis) infection. In subgroup analyses stratified by BMI and age, this association was only found significant in high age and BMI groups.ConclusionsThe cross-sectional study indicated a negative association between RBC folic acid and Trichomonas vaginalis infection, and latent effects of BMI and age on the association were also found.

【 授权许可】

CC BY   
© The Author(s) 2023

【 图 表 】

41116_2022_35_Article_IEq372.gif

41116_2022_35_Article_IEq362.gif

41116_2022_35_Article_IEq360.gif

Fig. 2

41116_2022_35_Article_IEq355.gif

41116_2022_35_Article_IEq341.gif