Triglyceride glucose index is associated with obstructive coronary artery disease in hypertensive patients

Cardiovascular Diabetology

Research

Da Yin¹  Fan Yang²  Weili Pan³  Minxian Wang³  Xinsheng Li³  Yongkui Ren³ 

[1] Department of Cardiology, Shenzhen People’s Hospital, 2nd Clinical Medical College of JINAN University, 1st Affiliated Hospital of the Southern University of Science and Technology. No. 1017 Dongmen North Road, Luohu District, Shenzhen, China;Department of Cardiology, the Affiliated Zhongshan Hospital of Dalian University, Dalian, Liaoning, China;Department of Cardiology, the First Affiliated Hospital of Dalian Medical University, Dalian, Liaoning, China;

关键词: TyG index;    Obstructive CAD;    Hypertensive patients;   

DOI  :  10.1186/s12933-023-01739-1

 received in 2022-11-25, accepted in 2023-01-06,  发布年份 2023

来源: Springer

【 摘 要 】

BackgroundHypertension is a leading risk of coronary artery disease (CAD). Triglyceride glucose index (TyG) is a surrogate of insulin resistance (IR). Few studies explore the association between TyG and the incidence of obstructive CAD (OCAD) in hypertensive patients.MethodsWe retrospectively screened 1841 hypertensive subjects who were free of a history of CAD and underwent coronary computed tomography angiography (CCTA) because of chest pain. TyG index was calculated as ln (fasting TG [mg/dL] * fasting glucose [mg/dL]/2). The outcome of this research was OCAD, which was defined as the presence of diameter stenosis ≥ 50% in any of the four major epicardial coronary arteries detected on CCTA.ResultsA total of 310 (16.8%) patients developed obstructive CAD. The restricted cubic spline (RCS) analysis showed a J-shaped relationship between TyG and OCAD and the OR for OCAD increased as the TyG rose over 8.61 (OR perSD) 1.64, 95% CI 1.13–2.54, p = 0.008). After full adjustments for confounding covariates, patients with TyG index in tertile 3 (T3) had 2.12 times (95% CI 1.80 to 3.81) and in T2 had 2.01 times (95% CI 1.40 to 2.88) as high as the risk of OCAD compared with patients in T1 (p for trend = 0.001). When regarding TyG as a continuous variable, 1-SD increase elevated 49% (OR (95%CI), 1.49 (1.30–1.74)) risk of obstructive CAD (p = 0.007). This positive effect was still consistent across the subgroups (p for interaction > 0.05).ConclusionTyG index was associated with the incidence of obstructive CAD in hypertensive patients.

【 授权许可】

CC BY   
© The Author(s) 2023

【 图 表 】

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