期刊论文详细信息
Journal of Biomedical Science
Epigenetic remodeling of the immune landscape in cancer: therapeutic hurdles and opportunities
Review
Hsuan-Hsuan Lu1  Feng-Ming Tien2  Shu-Yung Lin2  Hsing-Chen Tsai3 
[1] Department of Internal Medicine, National Taiwan University Hospital, 100225, Taipei, Taiwan;Center for Frontier Medicine, National Taiwan University Hospital, 100225, Taipei, Taiwan;Department of Internal Medicine, National Taiwan University Hospital, 100225, Taipei, Taiwan;Graduate Institute of Clinical Medicine, College of Medicine, National Taiwan University, 100233, Taipei, Taiwan;Department of Internal Medicine, National Taiwan University Hospital, 100225, Taipei, Taiwan;Graduate Institute of Clinical Medicine, College of Medicine, National Taiwan University, 100233, Taipei, Taiwan;Center for Frontier Medicine, National Taiwan University Hospital, 100225, Taipei, Taiwan;Graduate Institute of Toxicology, College of Medicine, National Taiwan University, No. 1 Jen Ai Road Section 1, Rm542, 100233, Taipei, Taiwan;Department of Medical Research, National Taiwan University Hospital, 100225, Taipei, Taiwan;
关键词: Tumor immune microenvironment;    Epigenetic therapy;    Immunotherapy;    DNA methylation;    Histone modifications;    Chromatin accessibility;    Innate immunity;    Adaptive immunity;   
DOI  :  10.1186/s12929-022-00893-0
 received in 2022-08-08, accepted in 2022-12-19,  发布年份 2022
来源: Springer
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【 摘 要 】

The tumor immune microenvironment represents a sophisticated ecosystem where various immune cell subtypes communicate with cancer cells and stromal cells. The dynamic cellular composition and functional characteristics of the immune landscape along the trajectory of cancer development greatly impact the therapeutic efficacy and clinical outcome in patients receiving systemic antitumor therapy. Mounting evidence has suggested that epigenetic mechanisms are the underpinning of many aspects of antitumor immunity and facilitate immune state transitions during differentiation, activation, inhibition, or dysfunction. Thus, targeting epigenetic modifiers to remodel the immune microenvironment holds great potential as an integral part of anticancer regimens. In this review, we summarize the epigenetic profiles and key epigenetic modifiers in individual immune cell types that define the functional coordinates of tumor permissive and non-permissive immune landscapes. We discuss the immunomodulatory roles of current and prospective epigenetic therapeutic agents, which may open new opportunities in enhancing cancer immunotherapy or overcoming existing therapeutic challenges in the management of cancer.

【 授权许可】

CC BY   
© The Author(s) 2023

【 预 览 】
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