Modulatory activity of testosterone on growth pattern and IGF-1 levels in vanishing testis syndrome: a case report during 15 years of follow-up

BMC Endocrine Disorders

Case Report

Carlo Trombetta¹  Diego Ferone²  Manuela Albertelli²  Mara Boschetti²  Keyvan Khorrami Chokami²  Federico Gatto³  Francesco Cocchiara³  Marta Franco⁴  Claudia Teti⁵ 

[1] Department of Medicine, Surgery and Health Sciences, Urological Clinic, University of Trieste, Trieste, Italy;Endocrinology Unit, Department of Internal Medicine & Medical Specialties (DiMI), IRCCS Ospedale Policlinico San Martino, University of Genoa, Viale Benedetto XV, 16132, Genoa, Italy;Endocrinology Unit, IRCCS Ospedale Policlinico San Martino, Genoa, Italy;Endocrinology Unit, UOSD Azienda Ospedaliera San Camillo-Forlanini, Rome, Italy;Endocrinology, Diabetology and Metabolic Diseases Unit, ASL1, Imperia, Italy;

关键词: Growth;    Puberty;    Hypogonadism;    IGF-1;    Testosterone;    Case report;   

DOI  :  10.1186/s12902-022-01258-2

 received in 2022-11-11, accepted in 2022-12-21,  发布年份 2022

来源: Springer

【 摘 要 】

BackgroundThe vanishing testis syndrome (VTS), is a 46, XY disorder of sex development (46, XY DSD) and is characterized by the absence of testis in a 46, XY subject with male genitalia, gonadal dysgenesis and consequent hypergonadotropic hypogonadism.Case presentationA young man affected by VTS has been followed up for more than 15-year in our center. The patient received different testosterone formulations, which modulated his IGF-1 levels and height velocity, depending on different stimulatory effects, mimicking pubertal spurt until achieving a final height in line with his genetic target.Exogenous testosterone, activating GH/IGF-1 system, can directly influence growth pattern. With this particular case report we demonstrate that an accurate monitoring of patients with VTS, as well as a perfect reproduction of testosterone secretion during pubertal spurt, can guarantee a normal growth and development and, consequently, a high level of quality of life in adulthood.ConclusionTestosterone levels act an important role during pubertal spurt in modulating the GH/IGF-1 axis, besides its well-known impact in sexual development.Very little amount of exogenous testosterone can stimulate IGF-1 secretion and provide to growth velocity the drive that characterizes the initial phases of the growth spurt.

【 授权许可】

CC BY   
© The Author(s) 2023

【 图 表 】

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