The influence of male and female overweight/obesity on IVF outcomes: a cohort study based on registration in Western China

Reproductive Health

Research

Zhou Zhang¹  Jianhua Sun¹  Shengjia Shi¹  Yuan He¹  Junping Xing²  Tie Chong³  Xiang Liu⁴ 

[1] Reproductive Center of Northwest Women’s and Children’s Hospital, 710061, Xi’an, Shaanxi, China;The First Affiliated Hospital of Xi’an Jiao Tong University, 710061, Xi’an, Shaanxi, China;The Second Affiliated Hospital of Xi’an Jiao Tong University, 710004, Xi’an, Shaanxi, China;The Second Affiliated Hospital of Xi’an Jiao Tong University, 710004, Xi’an, Shaanxi, China;Reproductive Center of Northwest Women’s and Children’s Hospital, 710061, Xi’an, Shaanxi, China;

关键词: Overweight/obesity;    BMI;    In vitro fertilization-embryo transfer (IVF-ET);    CPR;    LBR;   

DOI  :  10.1186/s12978-022-01558-9

 received in 2022-05-18, accepted in 2022-12-22,  发布年份 2022

来源: Springer

【 摘 要 】

BackgroundOverweight/obesity can affect fertility, increase the risk of pregnancy complications, and affect the outcome of assisted reproductive technology (ART). However, due to confounding factors, the accuracy and uniformity of published findings on IVF outcomes have been disputed. This study aimed to assess the effects of both male and female body mass index (BMI), individually and in combination, on IVF outcomes.MethodsThis retrospective cohort study included 11,191 couples undergoing IVF. Per the Chinese BMI standard, the couples were divided into four groups: normal; female overweight/obesity; male overweight/obesity; and combined male and female overweight/obesity. The IVF outcomes of the four groups were compared and analysed.ResultsRegarding the 6569 first fresh IVF-ET cycles, compared with the normal weight group, the female overweight/obesity and combined male/female overweight/obesity groups had much lower numbers of available embryos and high-quality embryos (p < 0.05); additionally, the fertilization (p < 0.001) and normal fertilization rates (p < 0.001) were significantly decreased in the female overweight/obesity group. The combined male/female overweight/obesity group had significant reductions in the available embryo (p = 0.002), high-quality embryo (p = 0.010), fertilization (p = 0.001) and normal fertilization rates (p < 0.001); however, neither male or female overweight/obesity nor their combination significantly affected the clinical pregnancy rate (CPR), live birth rate (LBR) or abortion rate (p > 0.05).ConclusionOur findings support the notion that overweight/obesity does not influence pregnancy success; however, we found that overweight/obesity affects the fertilization rate and embryo number and that there are sex differences.

【 授权许可】

CC BY   
© The Author(s) 2022