Feasibility of a combined intermittent theta-burst stimulation and video game-based dexterity training in Parkinson’s disease

Journal of NeuroEngineering and Rehabilitation

Research

Simona Wapp¹  Tim Vanbellingen²  Manuela Pastore-Wapp²  Thomas Nyffeler³  Stephan Bohlhalter⁴  Brigitte C. Kaufmann⁵ 

[1] Neurocenter, Luzerner Kantonsspital, Lucerne, Switzerland;Neurocenter, Luzerner Kantonsspital, Lucerne, Switzerland;ARTORG Center for Biomedical Engineering Research, Gerontechnology and Rehabilitation Group, University of Bern, Bern, Switzerland;Neurocenter, Luzerner Kantonsspital, Lucerne, Switzerland;ARTORG Center for Biomedical Engineering Research, Gerontechnology and Rehabilitation Group, University of Bern, Bern, Switzerland;Department of Neurology, Inselspital, University Hospital, University of Bern, Bern, Switzerland;Neurocenter, Luzerner Kantonsspital, Lucerne, Switzerland;Department of Neurology, University of Zurich, Zurich, Switzerland;Neurocenter, Luzerner Kantonsspital, Lucerne, Switzerland;Sorbonne Université, Institut du Cerveau – Paris Brain Institute – ICM, Inserm, CNRS, Paris, France;Department of Neurology, Inselspital, University Hospital, University of Bern, Bern, Switzerland;

关键词: Parkinson’s disease;    Dexterity;    Video game-based training;    Intermittent theta-burst stimulation;    Feasibility;   

DOI  :  10.1186/s12984-023-01123-w

 received in 2022-08-11, accepted in 2023-01-03,  发布年份 2023

来源: Springer

【 摘 要 】

BackgroundPersons with Parkinson’s disease (PD) often exhibit difficulties with dexterity during the performance of activities of daily living (ADL), inter alia due to dysfunctional supplementary motor area (SMA). Combined intermittent theta-burst stimulation (iTBS) over the SMA followed by video game-based training (VBT) may therefore improve dexterity related ADL. The VBT may induce high flow levels related to high performance during the training. The aim of this study is to evaluate the feasibility of a combined iTBS-VBT intervention in persons with PD.MethodsA total of nine persons with PD (mean age 63.3 ± 8.76 years) with self-reported difficulties with dexterity related ADL were included in this pilot iTBS-VBT study. All participants received either iTBS or sham stimulation over the SMA followed by a 45-min VBT, three times a week for a total of three weeks. Feasibility was measured by means of the adherence rate and the system usability (System Usability Scale). Moreover, flow was measured after the last VBT session.ResultsAdherence rate was excellent with 100%. High system usability scores (i.e., mean 80%, range 55–97.5) and a significant Spearman’s correlation with the Flow State Scale (r = .762, p = .017) further point to the high feasibility of the VBT. Neither demographic variables nor difficulties in dexterity related ADL affected the usability of the VBT.ConclusionThis study demonstrates the high feasibility of a combined iTBS-VBT intervention. Moreover, the level of self-reported usability was related to flow experience. Whether this kind of combined iTBS-VBT intervention improves dexterity will be evaluated in a randomized controlled trial.Trial registration clincaltrials.gov NCT04699149, date of registration 1. June 2021

【 授权许可】

CC BY   
© The Author(s) 2023