The genome of sheep ked (Melophagus ovinus) reveals potential mechanisms underlying reproduction and narrower ecological niches

BMC Genomics

Research

Qingsong Zhou¹  Hongxuan He²  Shuyi Han²  Ye Wang²  Qingxun Zhang³  Ying Li⁴ 

[1]Key Laboratory of Zoological Systematics and Evolution, Institute of Zoology, Chinese Academy of Sciences, 100101, Beijing, China

[2]National Research Center for Wildlife-Borne Diseases, Institute of Zoology, Chinese Academy of Sciences, 100101, Beijing, China

[3]National Research Center for Wildlife-Borne Diseases, Institute of Zoology, Chinese Academy of Sciences, 100101, Beijing, China

[4]Beijing Milu Ecological Research Center, 100076, Beijing, China

[5]State Key Laboratory of Plateau Ecology and Agriculture, Qinghai University, 810016, Xining, China

关键词: Melophagus ovinus;    Pathogen diversity;    Genetic diversity;    Whole-genome;    Gene family evolution;   

DOI  :  10.1186/s12864-023-09155-1

 received in 2022-09-16, accepted in 2023-01-27,  发布年份 2023

来源: Springer

【 摘 要 】

BackgroundMelophagus ovinus is considered to be of great veterinary health significance. However, little is known about the information on genetic mechanisms of the specific biological characteristics and novel methods for controlling M. ovinus.ResultsIn total, the de novo genome assembly of M. ovinus was 188.421 Mb in size (330 scaffolds, N50 Length: 10.666 Mb), with a mean GC content of 27.74%. A total of 13,372 protein-coding genes were functionally annotated. Phylogenetic analysis indicated that the diversification of M. ovinus and Glossina fuscipes took place 72.76 Mya within the Late Cretaceous. Gene family expansion and contraction analysis revealed that M. ovinus has 65 rapidly-evolving families (26 expansion and 39 contractions) mainly involved DNA metabolic activity, transposases activity, odorant receptor 59a/67d-like, IMD domain-containing protein, and cuticle protein, etc. The universal and tightly conserved list of milk protein orthologues has been assembled from the genome of M. ovinus. Contractions and losses of sensory receptors and vision-associated Rhodopsin genes were significant in M. ovinus, which indicate that the M. ovinus has narrower ecological niches.ConclusionsWe sequenced, assembled, and annotated the whole genome sequence of M. ovinus, and launches into the preliminary genetic mechanisms analysis of the adaptive evolution characteristics of M. ovinus. These resources will provide insights to understand the biological underpinnings of this parasite and the disease control strategies.

【 授权许可】

CC BY   
© The Author(s) 2023

【 图 表 】

41116_2022_35_Article_IEq10.gif

Fig. 3

40249_2022_1049_Article_IEq53.gif

Fig. 8

42004_2022_803_Article_IEq36.gif

42004_2022_800_Article_IEq86.gif