Placental DNA methylation profile as predicting marker for autism spectrum disorder (ASD)

Molecular Medicine

Mini-Review

Amin Ravaei¹  Michele Rubini¹  Giovanni Nazzaro²  Marco Emanuele²  Luciano Fadiga² 

[1] Medical Genetics Laboratory, Department of Neuroscience and Rehabilitation, University of Ferrara, Via Fossato di Mortara 74, 44121, Ferrara, Italy;Section of Physiology, Department of Neuroscience and Rehabilitation, University of Ferrara, Ferrara, Italy;IIT@UniFe Center for Translational Neurophysiology of Speech and Communication (CTNSC), Istituto Italiano di Tecnologia, Ferrara, Italy;

关键词: Autism;    Placenta;    DNA methylation;    Brain;    Epigenetic;   

DOI  :  10.1186/s10020-022-00593-3

 received in 2022-10-14, accepted in 2022-12-15,  发布年份 2022

来源: Springer

【 摘 要 】

Autism spectrum disorder (ASD) is a neurodevelopmental disorder that impairs normal brain development and socio-cognitive abilities. The pathogenesis of this condition points out the involvement of genetic and environmental factors during in-utero life. Placenta, as an interface tissue between mother and fetus, provides developing fetus requirements and exposes it to maternal environment as well. Therefore, the alteration of DNA methylation as epigenetic consequence of gene-environmental interaction in the placenta could shed light on ASD pathogenesis. In this study, we reviewed the current findings on placental methylation status and its association with ASD. Differentially methylated regions (DMRs) in ASD-developing placenta were found to be mainly enriched in ASD gene loci affecting synaptogenesis, microtubule dynamics, neurogenesis and neuritogenesis. In addition, non-genic DMRs in ASD-placenta proposes an alternative contributing mechanism for ASD development. Our study highlights the importance of placental DNA methylation signature as a biomarker for ASD prediction.

【 授权许可】

CC BY   
© The Author(s) 2023