The worsening effect of anemia on left ventricular function and global strain in type 2 diabetes mellitus patients: a 3.0 T CMR feature tracking study

Cardiovascular Diabetology

Research

Ying-Kun Guo¹  Rong Xu¹  Han Fang²  Li jiang²  Wen-Lei Qian²  Rui Shi²  Yuan Li²  Zhi-Gang Yang² 

[1] Department of Radiology, Key Laboratory of Obstetric & Gynecologic and Pediatric Diseases and Birth Defects of Ministry of Education, West China Second University Hospital, Sichuan University, 20# South Renmin Road, 610041, Chengdu, Sichuan, China;Department of Radiology, West China Hospital, Sichuan University, 37# Guo Xue Xiang, 610041, Chengdu, Sichuan, China;

关键词: Type 2 diabetes mellitus;    Anemia;    Hemoglobin;    Cardiac magnetic resonance;    Feature tracking;    Left ventricular function;   

DOI  :  10.1186/s12933-023-01745-3

 received in 2023-01-01, accepted in 2023-01-17,  发布年份 2023

来源: Springer

【 摘 要 】

ObjectiveTo explore the additive effects of anemia on left ventricular (LV) global strains in patients with type 2 diabetes mellitus (T2DM) with or without anemia via cardiac magnetic resonance (CMR) feature tracking technology.Materials and methods236 T2DM patients with or without anemia and 67 controls who underwent CMR examination were retrospectively enrolled. LV function parameters, LV global radial peak strain (GRPS), longitudinal peak strain (GLPS), and circumferential peak strain (GCPS) were used to analyze the function and global strain of the heart. One-way analysis of variance and the chi-square test were used for intergroup analysis. Multivariable linear regression analysis was performed for the two T2DM groups to explore factors associated with LV global strains.ResultsThe T2DM group with anemia was oldest and had a lowest hemoglobin (Hb) concentration, lowest estimated glomerular filtration rate, highest LV end-systolic volume index, highest end-diastolic volume index and highest LV mass index than the control group and T2DM without anemia group (all P ≤ 0.001). Besides, The LV global peak strains in all three directions worsened successively from the control group to the T2DM without anemia group to the T2DM with anemia group (all p < 0.001). Among all clinical indices, the decrease in Hb was independently associated with the worsening in GRPS (β = 0.237, p = 0.001), GCPS (β = 0.326, p < 0.001), and GLPS (β = 0.265, p < 0.001).ConclusionAnemia has additive deleterious effects on LV function and LV global strains in patients with T2DM. Regular detection and early intervention of anemia might be beneficial for T2DM patients.

【 授权许可】

CC BY   
© The Author(s) 2023

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