Parkin coregulates glutathione metabolism in adult mammalian brain

Acta Neuropathologica Communications

Research

Rajiv R. Ratan¹  Carina Palmberg²  Arne Holmgren²  Rajib Sengupta³  Chantal Pileggi⁴  Mary-Ellen Harper⁴  Gary S. Shaw⁵  Matthew J. LaVoie⁶  Masashi Takanashi⁷  Nobutaka Hattori⁷  Chet E. Holterman⁸  Christopher R. Kennedy⁸  Bojan Shutinoski⁹  Juan Li⁹  Qiubo Jiang⁹  Heather Boston⁹  Nathalie A. Lengacher^1,10  Travis K. Fehr^1,10  Daniel N. El Kodsi^1,10  Jacqueline M. Tokarew^1,10  Ajanta Chatterji^1,10  Michael G. Schlossmacher^1,11  Angela P. Nguyen^1,12  Julianna J. Tomlinson^1,13 

[1] Burke Neurological Institute, Weill Cornell Medical School, White Plains, NY, USA;Department of Biochemistry, Karolinska Institute, Stockholm, Sweden;Department of Biochemistry, Karolinska Institute, Stockholm, Sweden;Amity Institute of Biotechnology, Amity University, Kolkata, West Bengal, India;Department of Biochemistry, Microbiology and Immunology Faculty of Medicine, and Ottawa Institute of Systems Biology, University of Ottawa, Ottawa, ON, Canada;Department of Biochemistry, University of Western Ontario, London, ON, Canada;Department of Neurology, College of Medicine, University of Florida, Gainesville, FL, USA;Department of Neurology, Juntendo University School of Medicine, Tokyo, Japan;Kidney Research Center, Ottawa Hospital Research Institute, Ottawa, ON, Canada;Program in Neuroscience, Ottawa Hospital Research Institute, Ottawa, ON, Canada;Program in Neuroscience, Ottawa Hospital Research Institute, Ottawa, ON, Canada;Department of Cellular and Molecular Medicine, University of Ottawa, Ottawa, ON, Canada;Program in Neuroscience, Ottawa Hospital Research Institute, Ottawa, ON, Canada;Department of Cellular and Molecular Medicine, University of Ottawa, Ottawa, ON, Canada;University of Ottawa Brain and Mind Research Institute, Ottawa, ON, Canada;Division of Neurology, Department of Medicine, The Ottawa Hospital, Ottawa, ON, Canada;Program in Neuroscience, Ottawa Hospital Research Institute, Ottawa, ON, Canada;Snyder Institute, University of Calgary, Calgary, AB, Canada;Program in Neuroscience, Ottawa Hospital Research Institute, Ottawa, ON, Canada;University of Ottawa Brain and Mind Research Institute, Ottawa, ON, Canada;

关键词: Early-onset Parkinson disease;    Parkin;    Prkn;    Sod2;    Redox stress;    Glutathione metabolism;    Mass spectrometry;    Posttranslational modification;   

DOI  :  10.1186/s40478-022-01488-4

 received in 2022-11-30, accepted in 2022-12-01,  发布年份 2022

来源: Springer

【 授权许可】

CC BY   
© The Author(s) 2023

【 图 表 】

41116_2022_35_Article_IEq574.gif

41116_2022_35_Article_IEq573.gif

Fig. 2

Fig. 42

41116_2022_35_Article_IEq564.gif

41116_2022_35_Article_IEq560.gif

41116_2022_35_Article_IEq557.gif

41116_2022_35_Article_IEq544.gif

41116_2022_35_Article_IEq530.gif

41116_2022_35_Article_IEq493.gif