Sexual dimorphism in selenium deficiency is associated with metabolic syndrome and prevalence of heart disease

Cardiovascular Diabetology

Research

Marco Metra¹  Dirk J. van Veldhuisen²  Ali A. Al-Mubarak²  Eerde H. Weening²  Martin M. Dokter²  Rudolf A. de Boer²  Adriaan A. Voors²  Nils Bomer²  Peter van der Meer²  Leong L. Ng³  Daan J. Touw⁴  Chim C. Lang⁵  Stephan J. L. Bakker⁶  Ron T. Gansevoort⁶  Kenneth Dickstein⁷ 

[1] Cardiology, Department of Medical and Surgical Specialties, Radiological Sciences and Public Health, ASST Spedali Civili, University of Brescia, Brescia, Italy;Department of Cardiology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands;Department of Cardiovascular Sciences, University of Leicester, Glenfield Hospital and NIHR Leicester Biomedical Research Centre, LE3 9QP, Leicester, UK;Department of Clinical Pharmacy and Pharmacology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands;Division of Molecular & Clinical Medicine, University of Dundee, DD1 9SY, Dundee, UK;Division of Nephrology, Department of Internal Medicine, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands;University of Bergen, Stavanger University Hospital, Stavanger, Norway;

关键词: Sexual dimorphism;    Interaction;    Selenium;    Metabolic syndrome;    Heart failure;   

DOI  :  10.1186/s12933-022-01730-2

 received in 2022-10-06, accepted in 2022-12-21,  发布年份 2022

来源: Springer

【 摘 要 】

BackgroundSerum selenium levels have been associated with the incidence of heart failure (HF) and signs of the metabolic syndrome. In addition, notable differences have been reported between males and females in food intake and micronutrient metabolism, possibly explaining different health outcomes.ObjectiveOur objective was to elucidate sex-specific, cross-sectional phenotypic differences in the association of serum selenium concentrations with parameters of metabolic syndrome and HF.MethodsWe investigated data from individuals from a community-based cohort (PREVEND; N = 4288) and heart failure cohort (BIOSTAT-CHF; N = 1994). In both populations, cross-sectional analyses were performed for potential interaction (p < 0.1) between sex and serum selenium with overlapping signs and clinical parameters of the metabolic syndrome and HF.ResultsBaseline selenium levels of the total cohort were similar between PREVEND (85.7 μg/L) and BIOSTAT-CHF (89.1 μg/L). Females with lower selenium levels had a higher BMI and increased prevalence of diabetes than females with higher selenium, in both PREVEND (pinteraction < 0.001; pinteraction = 0.040, resp.) and BIOSTAT-CHF (pinteraction = 0.021; pinteraction = 0.024, resp.), while opposite associations were observed for males. Additionally, in females, but not in males, lower selenium was associated with a higher prevalence of myocardial infarction (MI) in PREVEND (pinteraction = 0.021) and BIOSTAT-CHF (pinteraction = 0.084).ConclusionLower selenium was associated with a higher BMI and increased prevalence of diabetes in females, opposite to males, and was also associated with more MI in females. Interventional studies are needed to validate this observation.

【 授权许可】

CC BY   
© The Author(s) 2023

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