Brain nuclear receptors and cardiovascular function

Cell & Bioscience

Review

Mengjie Wang¹  Yongjie Yang¹  Yong Xu² 

[1] Department of Pediatrics, USDA/ARS Children’s Nutrition Research Center, Baylor College of Medicine, Houston, TX, USA;Department of Pediatrics, USDA/ARS Children’s Nutrition Research Center, Baylor College of Medicine, Houston, TX, USA;Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX, USA;

关键词: Nuclear receptor;    Central nervous system;    Cardiovascular function;    Brain–heart interaction;   

DOI  :  10.1186/s13578-023-00962-3

 received in 2022-12-21, accepted in 2023-01-12,  发布年份 2023

来源: Springer

【 摘 要 】

Brain–heart interaction has raised up increasing attentions. Nuclear receptors (NRs) are abundantly expressed in the brain, and emerging evidence indicates that a number of these brain NRs regulate multiple aspects of cardiovascular diseases (CVDs), including hypertension, heart failure, atherosclerosis, etc. In this review, we will elaborate recent findings that have established the physiological relevance of brain NRs in the context of cardiovascular function. In addition, we will discuss the currently available evidence regarding the distinct neuronal populations that respond to brain NRs in the cardiovascular control. These findings suggest connections between cardiac control and brain dynamics through NR signaling, which may lead to novel tools for the treatment of pathological changes in the CVDs.

【 授权许可】

CC BY   
© The Author(s) 2023

【 图 表 】

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