Emerging role of microbiota derived outer membrane vesicles to preventive, therapeutic and diagnostic proposes

Infectious Agents and Cancer

Review

Seyed Reza Hosseini-Fard¹  Saba Jalalifar²  Gholamreza Irajian²  Hassan Morovati Khamsi³  Sajad Karampoor⁴  Bahar Bajelan⁵  Rasoul Mirzaei⁶ 

[1] Department of Biochemistry, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran;Department of Microbiology, School of Medicine, Iran University of Medical Sciences, Tehran, Iran;Microbial Biotechnology Research Center, University of Medical Sciences, Tehran, Iran;Department of Quality Control, Razi Vaccine and Serum Research Institute, Agricultural Research, Education and Extension Organization (AREEO), Karaj, Iran;Gastrointestinal and Liver Diseases Research Center, Iran University of Medical Sciences, Tehran, Iran;School of Medicine, Alborz University of Medical Sciences, Karaj, Iran;Venom and Biotherapeutics Molecules Lab, Medical Biotechnology Department, Biotechnology Research Center, Pasteur Institute of Iran, Tehran, Iran;

关键词: Microbiota;    Outer membrane vesicle;    Vaccine;    Adjuvant;    Drug delivery;    Biomarker;   

DOI  :  10.1186/s13027-023-00480-4

 received in 2022-07-10, accepted in 2023-01-12,  发布年份 2023

来源: Springer

【 摘 要 】

The role of gut microbiota and its products in human health and disease is profoundly investigated. The communication between gut microbiota and the host involves a complicated network of signaling pathways via biologically active molecules generated by intestinal microbiota. Some of these molecules could be assembled within nanoparticles known as outer membrane vesicles (OMVs). Recent studies propose that OMVs play a critical role in shaping immune responses, including homeostasis and acute inflammatory responses. Moreover, these OMVs have an immense capacity to be applied in medical research, such as OMV-based vaccines and drug delivery. This review presents a comprehensive overview of emerging knowledge about biogenesis, the role, and application of these bacterial-derived OMVs, including OMV-based vaccines, OMV adjuvants characteristics, OMV vehicles (in conjugated vaccines), cancer immunotherapy, and drug carriers and delivery systems. Moreover, we also highlight the significance of the potential role of these OMVs in diagnosis and therapy.

【 授权许可】

CC BY   
© The Author(s) 2023

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