Clinical verification of the relationship between serum lipid metabolism and immune activity in breast cancer patients treated with neoadjuvant chemotherapy

European Journal of Medical Research

Research

Wataru Goto¹  Tamami Morisaki¹  Shinichiro Kashiwagi¹  Yuka Asano¹  Koji Takada¹  Kana Ogisawa¹  Hiroaki Tanaka²  Masatsune Shibutani²  Kiyoshi Maeda² 

[1] Department of Breast Surgical Oncology, Osaka Metropolitan University Graduate School of Medicine, 1-4-3 Asahi-Machi, Abeno-Ku, 545-8585, Osaka, Japan;Department of Gastroenterological Surgery, Osaka Metropolitan University Graduate School of Medicine, 1-4-3 Asahi-Machi, Abeno-Ku, 545-8585, Osaka, Japan;

关键词: Breast cancer;    Tumor immune activity;    Lipid metabolism;    Neoadjuvant chemotherapy;   

DOI  :  10.1186/s40001-022-00964-w

 received in 2022-08-24, accepted in 2022-12-19,  发布年份 2022

来源: Springer

【 摘 要 】

BackgroundLipid metabolism has been recently reported to affect the prognosis and tumor immune activity in cancer patients. However, the effect of lipid metabolism on chemosensitivity in patients with breast cancer treated with neoadjuvant chemotherapy (NAC) remains unclear.MethodsWe examined 327 patients with breast cancer who were treated with NAC followed by curative surgery. The correlations between the serum levels of total cholesterol (TC) and triglyceride (TG) and the clinicopathological features, including the efficacy of NAC, neutrophil-to-lymphocyte ratio (NLR), and absolute lymphocyte count (ALC), were evaluated retrospectively.ResultsSerum TG levels were increased after NAC in all the subtypes, and the rate of change was the highest, especially in triple-negative breast cancer (TNBC) (21.0% → 48.1%). In addition, only TNBC patients with an objective response (OR) had significantly higher TG levels after NAC than those without (P = 0.049). Patients with a high ALC before NAC had significantly higher TG levels after NAC than patients with all breast cancer (P = 0.001), HER2-enriched breast cancer (P = 0.021), and TNBC (P = 0.008). Patients with a low NLR before NAC had significantly higher TG levels after NAC only among patients with TNBC (P = 0.025). In patients with human epidermal growth factor receptor 2-enriched breast cancer, the group with normal TC levels before NAC had significantly better OS than those with high TC levels (P = 0.013, log-rank test), and in patients with TNBC, the group with high TC levels after NAC had significantly better OS than those with normal TC levels (P = 0.014, log-rank test).ConclusionsGood systemic immune activity and chemosensitivity may be associated with lipid metabolism regulated by NAC in TNBC patients.

【 授权许可】

CC BY   
© The Author(s) 2022

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