Obesity at age 20 and weight gain during adulthood increase risk of total and premature all-cause mortality: findings from women attending breast screening in Manchester

BMC Women's Health

Research

Jack Cuzick¹  Adam Brentnall¹  Lee Malcomson²  Jill Fox³  Jake Southworth³  Mary Pegington⁴  Michelle Harvie⁵  Anthony Howell⁶  Elaine F. Harkness⁷  D. Gareth Evans⁸ 

[1] Centre for Cancer Prevention, Wolfson Institute of Preventive Medicine, Queen Mary University of London, London, UK;Division of Cancer Sciences, School of Medical Sciences, Faculty of Biology, Medicine and Health, The University of Manchester, Wilmslow Road, M20 4BX, Manchester, UK;The Prevent Breast Cancer Research Unit, The Nightingale Centre, Manchester University NHS Foundation Trust, M23 9LT, Manchester, UK;The Prevent Breast Cancer Research Unit, The Nightingale Centre, Manchester University NHS Foundation Trust, M23 9LT, Manchester, UK;Division of Cancer Sciences, School of Medical Sciences, Faculty of Biology, Medicine and Health, The University of Manchester, Wilmslow Road, M20 4BX, Manchester, UK;The Prevent Breast Cancer Research Unit, The Nightingale Centre, Manchester University NHS Foundation Trust, M23 9LT, Manchester, UK;Division of Cancer Sciences, School of Medical Sciences, Faculty of Biology, Medicine and Health, The University of Manchester, Wilmslow Road, M20 4BX, Manchester, UK;Manchester Breast Centre, Manchester Cancer Research Centre, University of Manchester, 555 Wilmslow Rd, M20 4GJ, Manchester, UK;The Prevent Breast Cancer Research Unit, The Nightingale Centre, Manchester University NHS Foundation Trust, M23 9LT, Manchester, UK;Division of Cancer Sciences, School of Medical Sciences, Faculty of Biology, Medicine and Health, The University of Manchester, Wilmslow Road, M20 4BX, Manchester, UK;Manchester Breast Centre, Manchester Cancer Research Centre, University of Manchester, 555 Wilmslow Rd, M20 4GJ, Manchester, UK;Department of Medical Oncology, The Christie NHS Foundation Trust, Wilmslow Rd, M20 4BX, Manchester, UK;The Prevent Breast Cancer Research Unit, The Nightingale Centre, Manchester University NHS Foundation Trust, M23 9LT, Manchester, UK;Division of Informatics, Imaging and Data Sciences, School of Health Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK;The Prevent Breast Cancer Research Unit, The Nightingale Centre, Manchester University NHS Foundation Trust, M23 9LT, Manchester, UK;Manchester Breast Centre, Manchester Cancer Research Centre, University of Manchester, 555 Wilmslow Rd, M20 4GJ, Manchester, UK;Division of Informatics, Imaging and Data Sciences, School of Health Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK;NW Genomic Laboratory Hub, Manchester Centre for Genomic Medicine, Manchester University Hospitals NHS Foundation Trust, Manchester, UK;Genomic Medicine, Division of Evolution and Genomic Sciences, The University of Manchester, St Mary’s Hospital, Manchester University NHS Foundation Trust, Oxford Road, M13 9WL, Manchester, UK;

关键词: Weight;    Obesity;    Women;    Mortality;    Premature mortality;    Breast screening;   

DOI  :  10.1186/s12905-023-02162-0

 received in 2022-09-01, accepted in 2023-01-04,  发布年份 2023

来源: Springer

【 摘 要 】

BackgroundObesity in early adulthood is associated with lower breast cancer rates in later life. This could be interpreted as a positive reinforcement of excess weight amongst younger women however, the wider implications of higher weights are less well known. This study examined the association between both obesity in early adulthood and body mass index (BMI) change through adulthood, and all-cause mortality.MethodsThe Predicting Risk of Cancer At Screening (PROCAS) study recruited 57,902 women aged 46–73 years (median age 57.2, IQR 51.8–63.7 years) from the Greater Manchester National Health Service breast screening programme in North West England between 2009 and 2015. It was used to assess associations between BMI at 20 years and cohort entry with all-cause mortality ascertained via deaths recorded on the National Breast Screening System to June 2020. Hazard ratios were estimated using proportional hazards (Cox) regression adjusted for factors at entry to the cohort: age, deprivation, bilateral oophorectomy, hormone-replacement therapy, menopausal status, ethnicity, alcohol intake, physical activity, and BMI.ResultsThe prevalence of overweight (25–30 kg/m2) and obesity (> 30 kg/m2) were 10.4% and 2.5% respectively at 20 years, increasing to 35.2% and 25.9% respectively at cohort entry. After a mean 8.7 years follow-up we observed that overweight (HR = 1.27, 95%CI = 1.10–1.47) and obesity (HR = 2.11, 95%CI = 1.67–2.66) at 20 years had a higher mortality rate compared with healthy weight. Women who were underweight/healthy weight at 20 years and gained weight to obesity at entry had a slightly increased mortality rate compared with women who were underweight/healthy weight at both time points (HR 1.16, 95%CI = 1.02–1.32). Women with overweight (HR = 1.36, 95%CI = 1.06–1.75) or obesity (HR = 1.90, 95%CI = 1.45–2.48) at both 20 years and entry had a higher mortality rate than women who were underweight/healthy weight at both points.ConclusionsWomen who self-reported overweight and obesity at 20 years had a shorter life expectancy in this cohort of women attending breast cancer screening. Weight gain from 20 years was common in this group. Girls and women should be supported to maintain a healthy weight throughout the lifespan to help increase life expectancy.Trial registration number NCT04359420, retrospectively registered 24/04/2020.

【 授权许可】

CC BY   
© The Author(s) 2023

【 图 表 】

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