In search of a ‘pan-European value set’; application for EQ-5D-3L

BMC Medical Research Methodology

Research

Judit Simon¹  Ayesha Sajjad²  Leona Hakkaart-van Roijen³  Matthijs M. Versteegh⁴  Irene Santi⁴  Jan Busschbach⁵ 

[1] Department of Health Economics, Center for Public Health, Medical University of Vienna, Vienna, Austria;Department of Psychiatry, University of Oxford, Oxford, UK;Erasmus School of Health Policy and Management, Erasmus University Rotterdam, Rotterdam, The Netherlands;Erasmus School of Health Policy and Management, Erasmus University Rotterdam, Rotterdam, The Netherlands;Institute for Medical Technology Assessment (iMTA), Erasmus University Rotterdam, Rotterdam, The Netherlands;Institute for Medical Technology Assessment (iMTA), Erasmus University Rotterdam, Rotterdam, The Netherlands;Section of Medical Psychology and Psychotherapy, Erasmus MC, Rotterdam, The Netherlands;

关键词: Utilities;    EQ-5D-3L;    Value set;    Time trade-off;    Europe;   

DOI  :  10.1186/s12874-022-01830-3

 received in 2022-03-22, accepted in 2022-12-23,  发布年份 2022

来源: Springer

【 摘 要 】

ObjectivesCountry-specific value sets for the EQ-5D are available which reflect preferences for health states elicited from the general population. This allows the transformation of responses on EQ-5D to health state utility values. Only twelve European countries possess country-specific value sets and no value set reflecting the preferences of Europe exists. We aim to estimate a ‘pan-European’ value set for the EQ-5D-3L, reflecting the preferences for health states of the European population that could help to evaluate health care from the perspective of the European decision-maker.MethodsWe systematically assessed and compared the methodologies of available EQ-5D-3L time trade-off (TTO) value sets from twelve European countries: Denmark, France, Germany, Hungary, Italy, Netherlands, Poland, Portugal, Romania, Slovenia, Spain and UK. Using their published coefficients, a dataset with utility values for all 243 health states was simulated. Different modelling techniques and model specifications including interaction terms were tested. Model selection was based on goodness-of-fit criteria. We also explored results with application of population size weights.ResultsMethodological, procedural and analytical characteristics of the included EQ-5D-3L valuation studies were quite comparable. An OLS based model was the preferred model to represent European preferences. Weighting with population size made little difference.ConclusionsEQ-5D-3L valuation studies were considered of sufficient comparability to form the basis for a new ‘pan-European’ value set. The method used allows for an easy update when new national value sets become available.

【 授权许可】

CC BY   
© The Author(s) 2023

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