A study on endovascular treatment alone and bridging treatment for acute ischemic stroke

European Journal of Medical Research

Research

Hao Zhu¹  Mijuan Zhang²  Bo Song²  Changfei Dai²  Feng Hua²  Jianbo Zhou²  Xiaojie Zhang²  Ping Chen²  Lin Li²  Lele Zhang²  Xiyang Ji²  Sa Wang²  Dong Wei²  Qun Zhang²  Zhao Jiang³ 

[1] Department of Neurology, First Hospital of Xianyang, No. 10, Biyuan Road, 712000, Xianyang, China;Department of Neurology, Xianyang Hospital of Yan’an University, No. 38 Wenlin Road, 712000, Xianyang, China;Department of Neurology, Xijing Hospital, Air Force Military Medical University, No.169, Changle West Road, 710032, Xi’an, China;

关键词: Artificial intelligence;    Endovascular treatment;    Mechanical thrombectomy;    Bridging treatment;    Acute ischemic stroke;   

DOI  :  10.1186/s40001-022-00966-8

 received in 2022-08-18, accepted in 2022-12-20,  发布年份 2022

来源: Springer

【 摘 要 】

ObjectivesTo investigate whether intravenous thrombolysis (IVT) with alteplase (a recombinant tissue plasminogen activator, rt-PA) before endovascular treatment (EVT) is beneficial for acute ischemic stroke (AIS) patients in different periods.MethodsThis study enrolled a total of 140 patients hospitalized between 2019 and 2022 with AIS from large vessel occlusion (LVO) in the anterior circulation. Those patients were divided into the EVT alone group and IVT + EVT group, in which EVT was preceded by intravenous rt-PA. According to the time from onset to femoral artery puncture, the above two groups were divided into the following subgroups: < 4.5 h, between 4.5 and 6 h, between 6 and 8 h, and between 8 and 10 h. There were 78 patients in the EVT alone group and 62 patients in the IVT + EVT group.ResultsThere was no statistically significant difference in functional independence, recanalization rate, favorable outcome rate, or mortality between the EVT and IVT + EVT groups (P > 0.05). After adjusting for confounding factors, a lower incidence of intracerebral hemorrhage was observed in the EVT group (P < 0.05). A comparison of time-dependent efficacy between the two groups showed that within 6–8 h, there were statistically significant differences between admission and postoperation in the National Institutes of Health Stroke Scale scores at 24 h (P = 0.01) or 7 days (P = 0.02).ConclusionsAlthough there was no difference in clinical efficacy and safety between the abovementioned two groups, treatment with IVT + EVT could increase the risk of bleeding compared to EVT. Moreover, in the 6–8 h subgroup, the efficacy of EVT alone was better than that of IVT + EVT.

【 授权许可】

CC BY   
© The Author(s) 2023

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