Metal ions and nanometallic materials in antitumor immunity: Function, application, and perspective

Journal of Nanobiotechnology

Review

Yan Fang¹  Yijia Wu¹  Min Zhou¹  Feiyang Shen¹  Jianfeng Shen²  Xianqun Fan² 

[1] Department of Ophthalmology, Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine, 200025, Shanghai, China;Shanghai Key Laboratory of Orbital Diseases and Ocular Oncology, 200025, Shanghai, China;Department of Ophthalmology, Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine, 200025, Shanghai, China;Shanghai Key Laboratory of Orbital Diseases and Ocular Oncology, 200025, Shanghai, China;Institute of Translational Medicine, National Facility for Translational Medicine, Shanghai Jiao Tong University, 200240, Shanghai, China;

关键词: Metal ions;    Nanometallic materials;    Cancer immunotherapy;    Nanotechnology;    Tumor microenvironment;   

DOI  :  10.1186/s12951-023-01771-z

 received in 2022-10-25, accepted in 2023-01-05,  发布年份 2023

来源: Springer

【 摘 要 】

The slightest change in the extra/intracellular concentration of metal ions results in amplified effects by signaling cascades that regulate both cell fate within the tumor microenvironment and immune status, which influences the network of antitumor immunity through various pathways. Based on the fact that metal ions influence the fate of cancer cells and participate in both innate and adaptive immunity, they are widely applied in antitumor therapy as immune modulators. Moreover, nanomedicine possesses the advantage of precise delivery and responsive release, which can perfectly remedy the drawbacks of metal ions, such as low target selectivity and systematic toxicity, thus providing an ideal platform for metal ion application in cancer treatment. Emerging evidence has shown that immunotherapy applied with nanometallic materials may significantly enhance therapeutic efficacy. Here, we focus on the physiopathology of metal ions in tumorigenesis and discuss several breakthroughs regarding the use of nanometallic materials in antitumor immunotherapeutics. These findings demonstrate the prominence of metal ion-based nanomedicine in cancer therapy and prophylaxis, providing many new ideas for basic immunity research and clinical application. Consequently, we provide innovative insights into the comprehensive understanding of the application of metal ions combined with nanomedicine in cancer immunotherapy in the past few years.Graphical Abstract

【 授权许可】

CC BY   
© The Author(s) 2023

【 图 表 】

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