The usefulness of tranexamic acid for bleeding symptoms of chronic consumptive coagulopathy complicated by aortic disease: a single-institute, retrospective study of 14 patients

Thrombosis Journal

Research

Tetsuhito Kojima¹  Takeshi Kanematsu²  Shuichi Okamoto²  Hitoshi Kiyoi³  Naruko Suzuki³  Yuka Kawaguchi³  Akira Katsumi⁴  Shogo Tamura⁵  Atsuo Suzuki⁶  Nobuaki Suzuki⁷  Tadashi Matsushita⁷ 

[1] Aichi Health Promotion Foundation, Nagoya, Japan;Department of Clinical Laboratory, Nagoya University Hospital, Nagoya, Japan;Department of Hematology and Oncology, Nagoya University Graduate School of Medicine, Nagoya, Japan;Department of Hematology, National Center of Geriatrics and Gerontology, Obu, Japan;Department of Integrated Health Sciences, Nagoya University Graduate School of Medicine, Nagoya, Japan;Present address: Department of Medical Laboratory Science, Hokkaido University Graduate School of Health Science, Sapporo, Japan;Department of Medical Technique, Nagoya University Hospital, Nagoya, Japan;Department of Transfusion Medicine, Nagoya University Hospital, Nagoya, Japan;

关键词: Disseminated intravascular coagulation;    Tranexamic acid;    Aortic aneurysm;    Aneurysm;    Dissecting;    Endovascular procedures;   

DOI  :  10.1186/s12959-022-00429-4

 received in 2022-07-29, accepted in 2022-11-04,  发布年份 2022

来源: Springer

【 摘 要 】

BackgroundTranexamic acid (TXA) is an antifibrinolytic drug that blocks lysine-binding sites on the profibrinolytic enzyme plasminogen. Aortic diseases with chronic consumption coagulopathy may lead to disseminated intravascular coagulation (DIC) and cause fatal bleeding. Although the use of antifibrinolytic agents in DIC is generally not recommended due to enhanced fibrin deposition risking thrombotic symptoms, the efficacy of TXA has been reported in several cases of DIC with aortic diseases. However, the efficacy and safety of TXA for bleeding symptoms of chronic consumption coagulopathy with aortic diseases have not been studied in detail.MethodsWe evaluated the efficacy of TXA in 14 patients with chronic consumptive coagulopathy due to aortic disease complicated by bleeding symptoms. Changes in coagulation and fibrinolysis parameters from baseline were analyzed with Wilcoxon matched-pairs signed-rank tests, excluding missing values. Kaplan-Meier curves were used to analyze overall survival.ResultsMedian age was 78.5 years (range, 66–89 years) and median observation period was 448 days (range, 0–2282 days). Twelve patients had chronic renal failure and 1 patient had chronic liver failure. Before starting treatment, median Japanese Ministry of Health and Welfare DIC diagnostic criteria score was 8 (range, 4–11) and median platelet count was 64 × 109/L (range, 25–97 × 109/L). Twelve patients underwent evaluation of bleeding symptoms after introduction of TXA, and 10 of those 12 patients showed improved bleeding tendencies within 30 days (median, 5.0 days). One patient with chronic liver failure showed worsening of bleeding symptoms. Although only one patient was initiated TXA in combination with anticoagulants, no significant worsening of thrombotic events was observed within 30 days.ConclusionsTXA therapy appears effective against chronic consumptive coagulopathy with bleeding due to aortic disease, with few side effects.

【 授权许可】

CC BY   
© The Author(s) 2023

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