Mitochondria-derived peptide MOTS-c: effects and mechanisms related to stress, metabolism and aging

Journal of Translational Medicine

Review

Xifeng Wang¹  Lieliang Zhang²  Wei Wan²  Xiuqing Rao²  Fuzhou Hua²  Yue Lin²  Jun Ying² 

[1]Department of Anesthesiology, The First Affiliated Hospital of Nanchang University, 330006, Nanchang, Jiangxi, China

[2]Department of Anesthesiology, The Second Affiliated Hospital of Nanchang University, 330006, Nanchang, Jiangxi, China

[3]Key Laboratory of Anesthesiology of Jiangxi Province, 1# Minde Road, 330006, Nanchang, Jiangxi, People’s Republic of China

关键词: MOTS-c;    Mitochondrial gene;    Stress response;    Aging;    Inflammation;   

DOI  :  10.1186/s12967-023-03885-2

 received in 2022-10-19, accepted in 2023-01-11,  发布年份 2023

来源: Springer

【 摘 要 】

MOTS-c is a peptide encoded by the short open reading frame of the mitochondrial 12S rRNA gene. It is significantly expressed in response to stress or exercise and translocated to the nucleus, where it regulates the expression of stress adaptation-related genes with antioxidant response elements (ARE). MOTS-c mainly acts through the Folate-AICAR-AMPK pathway, thereby influencing energy metabolism, insulin resistance, inflammatory response, exercise, aging and aging-related pathologies. Because of the potential role of MOTS-c in maintaining energy and stress homeostasis to promote healthy aging, especially in view of the increasing aging of the global population, it is highly pertinent to summarize the relevant studies. This review summarizes the retrograde signaling of MOTS-c toward the nucleus, the regulation of energy metabolism, stress homeostasis, and aging-related pathological processes, as well as the underlying molecular mechanisms.

【 授权许可】

CC BY   
© The Author(s) 2023

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