Alkaloids as potential antivirals. A comprehensive review

Natural Products and Bioprospecting

Review

Abdul-Hamid Emwas¹  Shah Faisal²  Bibi Kubra²  Syed Lal Badshah²  Mariusz Jaremko³ 

[1] Core Labs, King Abdullah University of Science and Technology (KAUST), 23955-6900, Thuwal, Saudi Arabia;Department of Chemistry, Islamia College University Peshawar, 25120, Peshawar, Pakistan;Division of Biological and Environmental Sciences and Engineering (BESE), Smart-Health Initiative (SHI) and Red Sea Research Center (RSRC), King Abdullah University of Science and Technology (KAUST), 23955-6900, Thuwal, Saudi Arabia;

关键词: Alkaloid antivirals;    Antiviral agents;    Antiviral phytochemicals;    In vitro;    Spread;    Inhibition;   

DOI  :  10.1007/s13659-022-00366-9

 received in 2022-10-25, accepted in 2022-12-01,  发布年份 2022

来源: Springer

【 摘 要 】

Alkaloids are a diverse group of natural phytochemicals. These phytochemicals in plants provide them protection against pests, and herbivorous organisms and also control their development. Numerous of these alkaloids have a variety of biological effects, and some have even been developed into medications with different medicinal properties. This review aims to provide a broad overview of the numerous naturally occurring alkaloids (isolated from both terrestrial and aquatic species) along with synthetically produced alkaloid compounds having prominent antiviral properties. Previous reviews on this subject have focused on the biological actions of both natural and synthetic alkaloids, but they have not gone into comprehensive detail about their antiviral properties. We reviewed here several antiviral alkaloids that have been described in the literature in different investigational environments i.e. (in-vivo, in-ovo, in-vitro, and in-silico), and found that these alkaloid compounds have significant antiviral properties against several infectious viruses. These alkaloids repressed and targeted various important stages of viral infection at non-toxic doses while some of the alkaloids reported here also exhibited comparable inhibitory activities to commercially used drugs. Overall, these anti-viral effects of alkaloids point to a high degree of specificity, implying that they could serve as effective and safe antiviral medicines if further pursued in medicinal and pharmacological investigations.

【 授权许可】

CC BY   
© The Author(s) 2023

【 图 表 】

Fig. 5

Fig. 1

Fig. 1

Fig. 5

42004_2022_800_Article_IEq32.gif

Fig. 4

Fig. 4

Fig. 2

40798_2022_490_Article_IEq58.gif

40798_2022_490_Article_IEq57.gif

40798_2022_490_Article_IEq56.gif

40798_2022_490_Article_IEq54.gif

40798_2022_490_Article_IEq52.gif

40798_2022_490_Article_IEq510.gif

Fig. 1

Fig. 2

40798_2022_490_Article_IEq48.gif

40798_2022_490_Article_IEq47.gif

40798_2022_490_Article_IEq45.gif

Fig. 4

40798_2022_490_Article_IEq42.gif

Fig. 1

40798_2022_490_Article_IEq41.gif

40798_2022_490_Article_IEq12.gif

40798_2022_490_Article_IEq9.gif

Fig. 3

40798_2022_490_Article_IEq5.gif

40798_2022_490_Article_IEq3.gif

40798_2022_490_Article_IEq2.gif

Fig. 1

40854_2022_439_Article_IEq93.gif

Fig. 3

Fig. 57

Fig. 1

Fig. 4

Fig. 1

Fig. 7

Fig. 56

Fig. 4

Fig. 55

Fig. 6

Fig. 5

Fig. 54

Fig. 2

Fig. 1

12864_2023_9114_Article_IEq10.gif

12888_2022_4500_Article_IEq3.gif

12888_2022_4500_Article_IEq2.gif

12888_2022_4500_Article_IEq1.gif

Fig. 1

Fig. 52

Fig. 11

Fig. 3

Fig. 10

Fig. 9

Fig. 6

Fig. 1

Fig. 8

Fig. 3

Fig. 49

Fig. 4

Fig. 7

Fig. 4

Fig. 2

Fig. 48

Fig. 1

Fig. 4

Fig. 2

Fig. 5

41116_2022_35_Article_IEq649.gif

41116_2022_35_Article_IEq641.gif