期刊论文

【摘要】

Mitochondria determine the physiological status of most eukaryotes. Mitochondrial dynamics plays an important role in maintaining mitochondrial homeostasis, and the disorder in mitochondrial dynamics could affect cellular energy metabolism leading to tumorigenesis. In recent years, disrupted mitochondrial dynamics has been found to influence the biological behaviors of gastrointestinal cancer with the potential to be a novel target for its individualized therapy. This review systematically introduced the role of mitochondrial dynamics in maintaining mitochondrial homeostasis, and further elaborated the effects of disrupted mitochondrial dynamics on the cellular biological behaviors of gastrointestinal cancer as well as its association with cancer progression. We aim to provide clues for elucidating the etiology and pathogenesis of gastrointestinal cancer from the perspective of mitochondrial homeostasis and disorder.

【授权许可】

CC BY
© The Author(s) 2023

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Journal of Translational Medicine
Association of mitochondrial homeostasis and dynamic balance with malignant biological behaviors of gastrointestinal cancer
Review
Li-rong Yan¹ Yuan Yuan¹ Qian Xu¹ Ao-ran Liu¹ Xiao-yang Wu¹ Zhi Lv¹ Zi-wei Yan¹ Li-ping Sun¹
[1] Tumor Etiology and Screening Department of Cancer Institute and General Surgery, The First Hospital of China Medical University, No. 155 North NanjingBei Street, Heping District, 110001, Shenyang, Liaoning, People’s Republic of China;Key Laboratory of Cancer Etiology and Prevention in Liaoning Education Department, The First Hospital of China Medical University, 110001, Shenyang, China;Key Laboratory of GI Cancer Etiology and Prevention in Liaoning Province, The First Hospital of China Medical University, 110001, Shenyang, China;
关键词: Mitochondria; Mitochondrial dynamic; Mitochondrial homeostasis; Gastrointestinal cancer; Fission; Fusion; Mitophagy; Mitochondrial quality control; Mitochondrial biogenesis;
DOI : 10.1186/s12967-023-03878-1
received in 2022-09-18, accepted in 2023-01-07, 发布年份 2023
来源: Springer
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【 参考文献 】

【摘要】

【授权许可】

【预览】

【图表】

【参考文献】