The Frail-LESS (LEss Sitting and Sarcopenia in Frail older adults) intervention to improve sarcopenia and maintain independent living via reductions in prolonged sitting: a randomised controlled feasibility trial protocol

Pilot and Feasibility Studies

Study Protocol

Marsha L. Brierley¹  Cherry Kilbride²  Daniel P. Bailey³  Jamie H. Harper³  Christina Victor⁴  David J. Hewson⁵  Angel M. Chater⁶ 

[1] Centre for Physical Activity in Health and Disease, Brunel University London, Kingston Lane, UB8 3PH, Uxbridge, UK;Centre for Physical Activity in Health and Disease, Brunel University London, Kingston Lane, UB8 3PH, Uxbridge, UK;Division of Physiotherapy and Physician Associates, Department of Health Sciences, Brunel University London, UB8 3PH, Uxbridge, UK;Centre for Physical Activity in Health and Disease, Brunel University London, Kingston Lane, UB8 3PH, Uxbridge, UK;Division of Sport, Health and Exercise Sciences, Department of Life Sciences, Brunel University London, UB8 3PH, Uxbridge, UK;Division of Global Public Health, Brunel University London, UB8 3PH, Uxbridge, UK;Institute for Health Research, University of Bedfordshire, LU1 3JU, Luton, UK;Institute for Sport and Physical Activity Research, University of Bedfordshire, Polhill Avenue, MK41 9EA, Bedford, UK;Centre for Behaviour Change, University College London, WC1E 7HB, London, UK;

关键词: Sarcopenia;    Frailty;    Sedentary behaviour;    Prolonged sitting;    Behaviour change;    activPAL;   

DOI  :  10.1186/s40814-022-01225-7

 received in 2022-07-19, accepted in 2022-12-01,  发布年份 2022

来源: Springer

【 摘 要 】

BackgroundSarcopenia is a progressive and generalised loss of muscle mass and function with advancing age and is a major contributor to frailty. These conditions lead to functional disability, loss of independence, and lower quality of life. Sedentary behaviour is adversely associated with sarcopenia and frailty. Reducing and breaking up sitting should thus be explored as an intervention target for their management. The primary aim of this study, therefore, is to examine the feasibility, safety, and acceptability of conducting a randomised controlled trial (RCT) that evaluates a remotely delivered intervention to improve sarcopenia and independent living via reducing and breaking up sitting in frail older adults.MethodsThis mixed-methods randomised controlled feasibility trial will recruit 60 community-dwelling older adults aged ≥ 65 years with very mild or mild frailty. After baseline measures, participants will be randomised to receive the Frail-LESS (LEss Sitting and Sarcopenia in Frail older adults) intervention or serve as controls (usual care) for 6 months. Frail-LESS is a remotely delivered intervention comprising of tailored feedback on sitting, information on the health risks of excess sitting, supported goal setting and action planning, a wearable device that tracks inactive time and provides alerts to move, health coaching, and peer support. Feasibility will be assessed in terms of recruitment, retention and data completion rates. A process evaluation will assess intervention acceptability, safety, and fidelity of the trial. The following measures will be taken at baseline, 3 months, and 6 months: sitting, standing, and stepping using a thigh-worn activPAL4 device, sarcopenia (via hand grip strength, muscle mass, and physical function), mood, wellbeing, and quality of life.DiscussionThis study will determine the feasibility, safety, and acceptability of evaluating a remote intervention to reduce and break up sitting to support improvements in sarcopenia and independent living in frail older adults. A future definitive RCT to determine intervention effectiveness will be informed by the study findings.Trial registrationISRCTN, ISRCTN17158017; Registered 6 August 2021, https://www.isrctn.com/ISRCTN17158017

【 授权许可】

CC BY   
© The Author(s) 2023

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