Predictors of time to first symptomatic recovery of major depressive disordered patients: a case study at Jimma University Medical Center

BMC Psychiatry

Research

Gurmessa Nugussu Gelcho¹  Jaleta Abdisa Fufa¹  Geremew Muleta Akessa¹  Firomsa Shewa Gari²  Tadele Degefa Bedada³  Ketema Zerihun Asefa³ 

[1] Department of Statistics, College of Natural Science, Jimma University, Jimma, Oromia, Ethiopia;Department of Statistics, College of Natural and Computational Science, Assosa University, Assosa, Benishangul Gumuz, Ethiopia;Department of Statistics, College of Natural and Computational Science, Madda Walabu University, Bale-Robe, Oromia, Ethiopia;

关键词: Major depressive disorder;    First symptomatic recovery;    Gamma;    Inverse gaussian;    Frailty;    Weibull;    Log-logistic;    Log-normal;    Akaike information criteria;   

DOI  :  10.1186/s12888-022-04443-8

 received in 2021-12-28, accepted in 2022-11-30,  发布年份 2022

来源: Springer

【 摘 要 】

BackgroundMajor Depressive Disorder is one of the most common mental disorders, and it is the main cause of disability worldwide with a prevalence ranging from 7 to 21%.ObjectiveThe goal of this study was to predict the time it took for patients with severe depressive disorders at Jimma University Medical Center to experience their initial symptomatic recovery.Study designThe researchers utilized a prospective study design.MethodsPatients with major depressive disorder were followed up on at Jimma University Medical Center from September 2018 to August 2020 for this study. The Gamma and Inverse Gaussian frailty distributions were employed with Weibull, Log-logistic, and Log-normal as baseline hazard functions. Akaike Information Criteria were used to choose the best model for describing the data.ResultsThis study comprised 366 patients, with 54.1% of them experiencing their first symptomatic recovery from a severe depressive disorder. The median time from the onset of symptoms to symptomatic recovery was 7 months. In the study area, there was a clustering effect in terms of time to first symptomatic recovery from major depressive disorder. According to the Log-normal Inverse-Gaussian frailty model, marital status, chewing khat, educational status, work status, substance addiction, and other co-variables were significant predictors of major depressive disorder (p-value < 0.05).ConclusionThe best model for describing the time to the first symptomatic recovery of major depressive disorder is the log-normal Inverse-Gaussian frailty model. Being educated and working considerably were the variables that reduces the time to first symptomatic recovery from major depressive disorder; whereas being divorced, chewing khat, substance abused and other co-factors were the variables that significantly extends the time to first symptomatic recovery.

【 授权许可】

CC BY   
© The Author(s) 2023

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