Clinical and laboratory characteristics of complex febrile seizures in the acute phase: a case-series study in Japan

BMC Neurology

Research

Ryojiro Tanaka¹  Azusa Maruyama²  Yusuke Ishida²  Daisaku Toyoshima²  Hiroshi Kurosawa³  Hiroki Takeda⁴  Kazumi Tomioka⁴  Hiroshi Yamaguchi⁴  Hiroaki Nagase⁴  Tsukasa Tanaka⁴  Kandai Nozu⁴  Masahiro Nishiyama⁵ 

[1] Department of Emergency and General Medicine, Hyogo Prefectural Kobe Children’s Hospital, Kobe, Japan;Department of Neurology, Hyogo Prefectural Kobe Children’s Hospital, Kobe, Japan;Department of Pediatric Critical Care Medicine, Hyogo Prefectural Kobe Children’s Hospital, Kobe, Japan;Department of Pediatrics, Kobe University Graduate School of Medicine, 7-5-2, Kusunoki-Cho, Chuo-Ku, 650-0017, Kobe, Hyogo, Japan;Department of Pediatrics, Kobe University Graduate School of Medicine, 7-5-2, Kusunoki-Cho, Chuo-Ku, 650-0017, Kobe, Hyogo, Japan;Department of Neurology, Hyogo Prefectural Kobe Children’s Hospital, Kobe, Japan;

关键词: Children;    Complex febrile seizures;    Encephalitis;    Encephalopathy;    Clinical characteristics;    Laboratory characteristics;   

DOI  :  10.1186/s12883-023-03051-7

 received in 2022-12-09, accepted in 2023-01-03,  发布年份 2023

来源: Springer

【 摘 要 】

BackgroundPatients with complex febrile seizures (CFS) often display abnormal laboratory results, unexpectedly prolonged seizures, and/or altered consciousness after admission. However, no standardized values have been established for the clinical and laboratory characteristics of CFS in the acute phase, making the management of CFS challenging. This study aimed to determine the clinical and laboratory characteristics of children with CFS during the acute phase. In particular, the duration of impaired consciousness and the detailed distribution of blood test values were focused.MethodsWe retrospectively reviewed medical records of a consecutive pediatric cohort aged 6–60 months who were diagnosed with CFS and admitted to Kobe Children’s Hospital between October 2002 and March 2017. During the study period, 486 seizure episodes with confirmed CFS were initially reviewed, with 317 seizure episodes included in the analysis. Detailed clinical and laboratory characteristics were summarized.ResultsAmong 317 seizure episodes (296 children with CFS), 302 required two or fewer anticonvulsants to be terminated. In 296 episodes showing convulsive seizures, median seizure duration was 30.5 min. The median time from onset to consciousness recovery was 175 min. Impaired consciousness lasting > 6, 8, and 12 h was observed in 13.9%, 7.6%, and 1.9% patients with CFS, respectively. Additionally, the distribution of aspartate aminotransferase, lactate dehydrogenase, creatinine, and glucose were clarified with 3, 10, 50, 90, and 97 percentile values.ConclusionThis study detailed the clinical and laboratory findings of acute-phase CFS using the data of the largest 15-year consecutive cohort of children with CFS. These results provide important information for appropriate acute management of CFS.

【 授权许可】

CC BY   
© The Author(s) 2023

【 图 表 】

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Fig. 59