Comparison of postoperative IL-6 and IL-10 levels following Erector Spinae Plane Block (ESPB) and classical Thoracolumbar Interfascial Plane (TLIP) block in a posterior lumbar decompression and stabilization procedure: a randomized controlled trial

BMC Anesthesiology

Research

Darto Satoto¹  Arif Hari Martono Marsaban¹  Raden Besthadi Sukmono¹  Aida Rosita Tantri¹  Rahmi Rahmi²  Ahmad Jabir Rahyussalim³ 

[1] Department of Anesthesiology and Intensive Care, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo National General Hospital, Jakarta, Indonesia;Department of Anesthesiology and Intensive Care, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo National General Hospital, Jakarta, Indonesia;Department of Anesthesiology and Intensive Care, Faculty of Medicine, Universitas Syiah Kuala, Banda Aceh, Indonesia;Department of Orthopedics and Traumatology, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo National General Hospital, Jakarta, Indonesia;

关键词: Block;    ESPB;    Regional anaesthesia;    TLIP;   

DOI  :  10.1186/s12871-023-01973-w

 received in 2022-07-26, accepted in 2023-01-04,  发布年份 2023

来源: Springer

【 摘 要 】

Background and objectivesThe erector spinae plane block (ESPB) and classical thoracolumbar interfascial plane (TLIP) block can reduce postoperative pain in lumbar surgery. In this study, we compared the efficacy of ESPB and classical TLIP block in providing perioperative analgesia in patients undergoing lumbar posterior decompression and stabilization by comparing postoperative pain, opioid consumption, and IL-6 and IL-10 serum concentrations between ESPB and classical TLIP block.MethodThis was a prospective, double-blinded, randomized controlled trial in tertiary referral hospitals. Forty patients were randomized into two equal groups, each receiving either ESPB or classical TLIP block. The primary outcome was the difference in IL-6 and IL-10 serum concentrations at baseline and 6 h after lumbar posterior decompression and stabilization. The secondary outcome was total opioid consumption and pain score 24 h post-operatively.ResultThere were no significant differences between the ESPB and classical TLIP block groups in pain score, IL-6 and IL-10 concentration change, and total opioid consumption post-operatively. There was a significant difference in the time until the first dose of morphine was needed between the ESPB and classical TLIP block groups (300 min vs. 547.5 min; p = 0.002).ConclusionESPB and classical TLIP block performance during lumbar surgery have comparable pain scores, IL-6 and IL-10 concentration differences pre- and post-operation, and total opioid consumption post-operatively. However, classical TLIP block provides a prolonged duration of analgesia.Trial registrationClinicalTrials.gov NCT04951024.

【 授权许可】

CC BY   
© The Author(s) 2023

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