Animal Microbiome | |
Short-term feeding of defatted bovine colostrum mitigates inflammation in the gut via changes in metabolites and microbiota in a chicken animal model | |
Research | |
Stanislaw Kahl1  Ted H. Elsasser1  Alan Cross2  Jacques Ravel3  Bing Ma3  Pawel Gajer3  | |
[1] Animal Biosciences and Biotechnology Laboratory, USA Department of Agriculture (USDA), Agricultural Research Service (ARS), 20705, Beltsville, MD, USA;Center for Vaccine Development and Global Health, University of Maryland School of Medicine, 21201, Baltimore, MD, USA;Institute for Genome Sciences, University of Maryland School of Medicine, 21201, Baltimore, MD, USA; | |
关键词: Anti-inflammation; Colostrum; Ileum; Immunometabolism; Metabolome; Gut microbiome; Protein tyrosine nitration; | |
DOI : 10.1186/s42523-023-00225-z | |
received in 2022-09-01, accepted in 2023-01-10, 发布年份 2023 | |
来源: Springer | |
![]() |
【 摘 要 】
BackgroundNondrug supplement strategies to improve gut health have largely focused on the effects of individual compounds to improve one aspect of gut homeostasis. However, there is no comprehensive assessment of the reproducible effects of oral, short-term, low-level colostrum supplementation on gut inflammation status that are specific to the ileum. Herein, a chicken animal model highly responsive to even mild gut inflammatory stimuli was employed to compare the outcomes of feeding a standard diet (CON) to those of CON supplemented with a centrifuge-defatted bovine colostrum (BC) or a nonfat dried milk (NFDM) control on the efficiency of nutrient use, ileal morphology, gut nitro-oxidative inflammation status, metabolites, and the composition of the microbiota.ResultsA repeated design, iterative multiple regression model was developed to analyze how BC affected ileal digesta-associated anti-inflammatory metabolite abundance coincident with observed changes in the ileal microbiome, mitigation of epithelial inflammation, and ileal surface morphology. An improved whole body nutrient use efficiency in the BC group (v CON and NFDM) coincided with the observed increased ileum absorptive surface and reduced epithelial cell content of tyrosine-nitrated protein (NT, biomarker of nitro-oxidative inflammatory stress). Metabolome analysis revealed that anti-inflammatory metabolites were significantly greater in abundance in BC-fed animals. BC also had a beneficial BC impact on microbiota, particularly in promoting the presence of the bacterial types associated with eubiosis and the segmented filamentous bacteria, Candidatus Arthromitus.ConclusionThe data suggest that an anti-inflammatory environment in the ileum was more evident in BC than in the other feeding groups and associated with an increased content of statistically definable groups of anti-inflammatory metabolites that appear to functionally link the observed interactions between the host’s improved gut health with an observed increase in whole body nutrient use efficiency, beneficial changes in the microbiome and immunometabolism.
【 授权许可】
CC BY
© The Author(s) 2023
【 预 览 】
Files | Size | Format | View |
---|---|---|---|
RO202305112677353ZK.pdf | 3354KB | ![]() |
|
41116_2022_35_Article_IEq397.gif | 1KB | Image | ![]() |
12888_2022_4443_Article_IEq1.gif | 1KB | Image | ![]() |
41116_2022_35_Article_IEq412.gif | 1KB | Image | ![]() |
12888_2022_4443_Article_IEq9.gif | 1KB | Image | ![]() |
41116_2022_35_Article_IEq434.gif | 1KB | Image | ![]() |
Fig. 11 | 127KB | Image | ![]() |
41116_2022_35_Article_IEq459.gif | 1KB | Image | ![]() |
Fig. 1 | 116KB | Image | ![]() |
41116_2022_35_Article_IEq462.gif | 1KB | Image | ![]() |
41116_2022_35_Article_IEq472.gif | 1KB | Image | ![]() |
41116_2022_35_Article_IEq493.gif | 1KB | Image | ![]() |
Fig. 1 | 125KB | Image | ![]() |
41116_2022_35_Article_IEq561.gif | 1KB | Image | ![]() |
Fig. 59 | 1107KB | Image | ![]() |
40798_2022_490_Article_IEq60.gif | 1KB | Image | ![]() |
Fig. 3 | 1769KB | Image | ![]() |
40798_2022_490_Article_IEq64.gif | 1KB | Image | ![]() |
Fig. 3 | 224KB | Image | ![]() |
13690_2022_1010_Article_IEq1.gif | 1KB | Image | ![]() |
【 图 表 】
13690_2022_1010_Article_IEq1.gif
Fig. 3
40798_2022_490_Article_IEq64.gif
Fig. 3
40798_2022_490_Article_IEq60.gif
Fig. 59
41116_2022_35_Article_IEq561.gif
Fig. 1
41116_2022_35_Article_IEq493.gif
41116_2022_35_Article_IEq472.gif
41116_2022_35_Article_IEq462.gif
Fig. 1
41116_2022_35_Article_IEq459.gif
Fig. 11
41116_2022_35_Article_IEq434.gif
12888_2022_4443_Article_IEq9.gif
41116_2022_35_Article_IEq412.gif
12888_2022_4443_Article_IEq1.gif
41116_2022_35_Article_IEq397.gif
【 参考文献 】
- [1]
- [2]
- [3]
- [4]
- [5]
- [6]
- [7]
- [8]
- [9]
- [10]
- [11]
- [12]
- [13]
- [14]
- [15]
- [16]
- [17]
- [18]
- [19]
- [20]
- [21]
- [22]
- [23]
- [24]
- [25]
- [26]
- [27]
- [28]
- [29]
- [30]
- [31]
- [32]
- [33]
- [34]
- [35]
- [36]
- [37]
- [38]
- [39]
- [40]
- [41]
- [42]
- [43]
- [44]
- [45]
- [46]
- [47]
- [48]
- [49]
- [50]
- [51]
- [52]
- [53]
- [54]
- [55]
- [56]
- [57]
- [58]
- [59]
- [60]
- [61]
- [62]
- [63]
- [64]
- [65]
- [66]
- [67]
- [68]
- [69]
- [70]
- [71]
- [72]
- [73]
- [74]
- [75]
- [76]
- [77]
- [78]
- [79]
- [80]
- [81]
- [82]
- [83]
- [84]
- [85]
- [86]
- [87]
- [88]
- [89]
- [90]
- [91]
- [92]
- [93]
- [94]
- [95]
- [96]
- [97]
- [98]
- [99]
- [100]
- [101]
- [102]
- [103]
- [104]
- [105]
- [106]
- [107]
- [108]
- [109]
- [110]
- [111]
- [112]
- [113]
- [114]
- [115]
- [116]
- [117]