Therapeutic effects of magnesium and vitamin B6 in alleviating the symptoms of restless legs syndrome: a randomized controlled clinical trial

BMC Complementary Medicine and Therapies

Research

Alireza Rezaei Ashtiani¹  Ali Jadidi²  Seyed Mohamad Aghaepour³  Ali Khanmohamadi Hezaveh³ 

[1] School of Medicine, Arak University of Medical Sciences, Arak, Iran;School of Nursing, Arak University of Medical Sciences, Arak, Iran;Traditional and Complementary Medicine Research Center, Arak University of Medical Sciences, Arak, Iran;Student Research Committee, Arak University of Medical Sciences, Arak, Iran;

关键词: Restless legs syndrome;    Willis-Ekbom Disease;    Magnesium;    Vitamin B6;    Pramipexole;    Sleep disorders;   

DOI  :  10.1186/s12906-022-03814-8

 received in 2022-07-10, accepted in 2022-11-30,  发布年份 2022

来源: Springer

【 摘 要 】

Background and objectiveRestless legs syndrome/Willis-Ekbom Disease (RLS/WED) is one of the most prevalent sleep disorders. There are contradicting data about the effectiveness of magnesium and vitamin B6 in alleviating the symptoms of this condition. Therefore, this study aimed to assess the efficacy of magnesium and vitamin B6 in alleviating the symptoms of RLS/WED.MethodsA single-blind study was conducted on individuals with this illness for at least three months. Randomly, 75 patients were assigned into three groups: magnesium, vitamin B6, and placebo. The experimental group received daily doses of 40 mg vitamin B6 or 250 mg magnesium oxide. While others in the control group merely received a placebo. Patients’ disease severity and sleep quality were evaluated three times using standard questionnaires (at the beginning of the study, one and two months after therapy). Utilizing SPSS22 software and the ANOVA, t-test, and repeated measure tests, statistical analysis was conducted.ResultsThe mean and standard deviation of sleep quality and disease severity at the beginning of the trial and throughout the first month following the intervention did not differ statistically between the three groups. In the second month following the intervention, the mean and standard deviation of sleep quality and disease severity were significantly different (P = 0.001).ConclusionTaking magnesium and vitamin B6 supplements can reduce the severity of symptoms of RLS/WED patients and improve their sleep quality.

【 授权许可】

CC BY   
© The Author(s) 2022