Journal of Biomedical Science | |
Chronic stress in solid tumor development: from mechanisms to interventions | |
Review | |
Hongsheng Li1  Yibing Chen2  Xinyu Hu3  Minhua Luo3  Jiajing Yan3  Zhengzhi Zou4  Quentin Liu5  | |
[1] Department of Breast Surgery, Affiliated Cancer Hospital & Institute of Guangzhou Medical University, 510095, Guangzhou, China;Department of Gynecology and Obstetrics, First Affiliated Hospital, Genetic and Prenatal Diagnosis Center, Zhengzhou University, 450001, Zhengzhou, China;MOE Key Laboratory of Laser Life Science & Guangdong Provincial Key Laboratory of Laser Life Science, College of Biophotonics, South China Normal University, 510631, Guangzhou, China;MOE Key Laboratory of Laser Life Science & Guangdong Provincial Key Laboratory of Laser Life Science, College of Biophotonics, South China Normal University, 510631, Guangzhou, China;Guangzhou Key Laboratory of Spectral Analysis and Functional Probes, College of Biophotonics, South China Normal University, 510631, Guangzhou, China;State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-Sen University Cancer Center, 510631, Guangzhou, China;Institute of Cancer Stem Cell, Dalian Medical University, 116044, Dalian, Liaoning, China; | |
关键词: Chronic stress; Tumor development; Tumor microenvironment; Cancer treatment; | |
DOI : 10.1186/s12929-023-00903-9 | |
received in 2022-10-28, accepted in 2023-01-17, 发布年份 2023 | |
来源: Springer | |
【 摘 要 】
Chronic stress results in disturbances of body hormones through the neuroendocrine system. Cancer patients often experience recurrent anxiety and restlessness during disease progression and treatment, which aggravates disease progression and hinders treatment effects. Recent studies have shown that chronic stress-regulated neuroendocrine systems secret hormones to activate many signaling pathways related to tumor development in tumor cells. The activated neuroendocrine system acts not only on tumor cells but also modulates the survival and metabolic changes of surrounding non-cancerous cells. Current clinical evidences also suggest that chronic stress affects the outcome of cancer treatment. However, in clinic, there is lack of effective treatment for chronic stress in cancer patients. In this review, we discuss the main mechanisms by which chronic stress regulates the tumor microenvironment, including functional regulation of tumor cells by stress hormones (stem cell-like properties, metastasis, angiogenesis, DNA damage accumulation, and apoptotic resistance), metabolic reprogramming and immune escape, and peritumor neuromodulation. Based on the current clinical treatment framework for cancer and chronic stress, we also summarize pharmacological and non-pharmacological therapeutic approaches to provide some directions for cancer therapy.
【 授权许可】
CC BY
© The Author(s) 2023
【 预 览 】
Files | Size | Format | View |
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RO202305112559511ZK.pdf | 4157KB | download | |
41116_2022_35_Article_IEq581.gif | 1KB | Image | download |
Fig. 3 | 301KB | Image | download |
Fig. 1 | 358KB | Image | download |
Fig. 52 | 1998KB | Image | download |
【 图 表 】
Fig. 52
Fig. 1
Fig. 3
41116_2022_35_Article_IEq581.gif
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