A comparison of pediatric inflammatory multisystem syndrome temporarily-associated with SARS-CoV-2 and Kawasaki disease

Scientific Reports

Article

Martin Roessler¹  Jochen Schmitt¹  Andreas Trotter²  Dominik T. Schneider³  André Jakob⁴  Maren Doenhardt⁵  Jakob Armann⁵  Reinhard Berner⁵  Natalie Diffloth⁵  Markus Hufnagel⁶  Anton Hospach⁷ 

[1] Center for Evidence-Based Healthcare, Medical Faculty Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany;Children’s Hospital and Center for Perinatal Medicine, Singen, Germany;Clinic of Pediatrics, Municipal Hospital Dortmund, Dortmund, Germany;Department of Pediatric Cardiology and Pediatric Intensive Care, Ludwig Maximilians University of Munich, Munich, Germany;Department of Pediatrics, University Hospital, Medical Faculty Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany;Division of Pediatric Infectious Diseases and Rheumatology, Department of Pediatrics and Adolescent Medicine, University Medical Center, Medical Faculty, University of Freiburg, Mathildenstr. 1, 79106, Freiburg, Germany;Olga-Hospital, Stuttgart, Germany;

DOI  :  10.1038/s41598-022-26832-5

 received in 2022-07-10, accepted in 2022-12-20,  发布年份 2022

来源: Springer

【 摘 要 】

The connection between Pediatric Inflammatory Multisystem Syndrome (PIMS) and Kawasaki Disease (KD) is not yet fully understood. Using the same national registry, clinical features and outcome of children hospitalized in Germany, and Innsbruck (Austria) were compared. Reported to the registry were 395 PIMS and 69 KD hospitalized patients. Patient age in PIMS cases was higher than in KD cases (median 7 [IQR 4–11] vs. 3 [IQR 1–4] years). A majority of both PIMS and KD patients were male and without comorbidities. PIMS patients more frequently presented with organ dysfunction, with the gastrointestinal (80%), cardiovascular (74%), and respiratory (52%) systems being most commonly affected. By contrast, KD patients more often displayed dermatological (99% vs. 68%) and mucosal changes (94% vs. 64%), plus cervical lymph node swelling (51% vs. 34%). Intensive care admission (48% vs. 19%), pulmonary support (32% vs. 10%), and use of inotropes/vasodilators (28% vs. 3%) were higher among PIMS cases. No patients died. Upon patient discharge, potentially irreversible sequelae—mainly cardiovascular—were reported (7% PIMS vs. 12% KD). Despite differences in age distribution and disease severity, PIMS and KD cases shared many common clinical and prognostic characteristics. This supports the hypothesis that the two entities represent a syndrome continuum.

【 授权许可】

CC BY   
© The Author(s) 2023

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