Gene signature and prognostic value of ubiquitination-related genes in endometrial cancer

World Journal of Surgical Oncology

Research

Xing Zhou¹  Wan Shu¹  Jun Zhang¹  Shuangshuang Cheng¹  Dilu Feng¹  Hongbo Wang¹  Rong Zhao¹  Yan Liu¹  Ziwei Wang¹ 

[1] Department of Obstetrics and Gynecology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, 430022, Wuhan, Hubei, People’s Republic of China;

关键词: Endometrial cancer;    Ubiquitination-related genes;    Prognostic model;    Survival;    Differentially expressed genes;    Tumor microenvironment;   

DOI  :  10.1186/s12957-022-02875-w

 received in 2022-06-05, accepted in 2022-12-09,  发布年份 2022

来源: Springer

【 摘 要 】

Protein ubiquitination is closely related to tumor occurrence and development. The specific role of ubiquitination in endometrial cancer remains largely unclear. Therefore, we constructed a novel endometrial cancer prognostic model based on ubiquitination-related genes. We extracted the expression matrices of ubiquitination-related genes from the Cancer Genome Atlas database, upon which we performed univariate Cox regression and least absolute shrinkage and selection operator (LASSO) regression analyses to obtain 22 ubiquitination-related genes for the construction of the prognostic model. Survival, regression, clinical correlation, and principal component analyses were performed to assess the performance of the model. Drug sensitivity analysis was performed based on these ubiquitination-related genes. Finally, a prognostic nomogram was constructed based on the prognostic model to quantify patient outcomes. Survival, regression, clinical correlation, and principal component analyses revealed that the performance of the prognostic model was satisfactory. Drug sensitivity analysis provided a potential direction for the treatment of endometrial cancer. The prognostic nomogram could be used to effectively estimate the survival rate of patients with endometrial cancer. In summary, we constructed a new endometrial cancer prognostic model and identified 5 differentially expressed, prognosis-associated, ubiquitination-related genes. These 5 genes are potential diagnostic and treatment targets for endometrial cancer.

【 授权许可】

CC BY   
© The Author(s) 2022

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