Combined metabolic activators improve cognitive functions in Alzheimer’s disease patients: a randomised, double-blinded, placebo-controlled phase-II trial

Translational Neurodegeneration

Research

Simon Lam¹  Jens Nielsen²  Hasan Turkez³  Ahmet Hacimuftuoglu⁴  Cemil Bayram⁴  Sena Oner⁵  Mehmet Enes Arslan⁵  Ozlem Ozdemir Tozlu⁵  Jan Borén⁶  Seyda Cankaya⁷  Ezgi Idil⁷  Ahmet Ozsimsek⁷  Rahim Nogaylar⁷  Burak Yulug⁷  Ebru Coskun⁸  Lutfu Hanoglu⁸  Serkan Yildirim⁹  Ismail Bolat⁹  Halil Aziz Velioglu^1,10  Ozlem Altay^1,11  Xiangyu Li^1,11  Hong Yang^1,11  Mathias Uhlén^1,11  Muhammad Arif^1,11  Saeed Shoaie^1,12  Adil Mardinoglu^1,12  Cheng Zhang^1,13 

[1] Centre for Host-Microbiome Interaction’s, Faculty of Dentistry, Oral and Craniofacial Sciences, King’s College London, London, UK;Department of Biology and Biological Engineering, Chalmers University of Technology, Gothenburg, Sweden;Department of Medical Biology, Faculty of Medicine, Atatürk University, Erzurum, Turkey;Department of Medical Pharmacology, Faculty of Medicine, Atatürk University, Erzurum, Turkey;Department of Molecular Biology and Genetics, Faculty of Science, Erzurum Technical University, Erzurum, Turkey;Department of Molecular and Clinical Medicine, University of Gothenburg and Sahlgrenska University Hospital, Gothenburg, Sweden;Department of Neurology and Neuroscience, Faculty of Medicine, Alanya Alaaddin Keykubat University, Antalya, Turkey;Department of Neurology, Faculty of Medicine, Istanbul Medipol University, Istanbul, Turkey;Department of Pathology, Veterinary Faculty, Ataturk University, Erzurum, Turkey;Department of Women’s and Children’s Health, Karolinska Institute, Stockholm, Sweden;Functional Imaging and Cognitive-Affective Neuroscience Lab, Istanbul Medipol University, Istanbul, Turkey;Science for Life Laboratory, KTH - Royal Institute of Technology, Stockholm, Sweden;Science for Life Laboratory, KTH - Royal Institute of Technology, Stockholm, Sweden;Centre for Host-Microbiome Interaction’s, Faculty of Dentistry, Oral and Craniofacial Sciences, King’s College London, London, UK;Science for Life Laboratory, KTH - Royal Institute of Technology, Stockholm, Sweden;School of Pharmaceutical Sciences, Zhengzhou University, Zhengzhou, People’s Republic of China;

关键词: Alzheimer’s disease;    Combined metabolic activators;    Multi-omics;    Systems biology;    Systems medicine;   

DOI  :  10.1186/s40035-023-00336-2

 received in 2022-10-24, accepted in 2023-01-09,  发布年份 2023

来源: Springer

【 授权许可】

CC BY   
© The Author(s) 2023

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