Longitudinal neurobehavioral profiles in children and young adults with PTEN hamartoma tumor syndrome and reliable methods for assessing neurobehavioral change

Journal of Neurodevelopmental Disorders

Research

Claire Sonneborn¹  Olivia Hogue²  Julian A. Martinez-Agosto³  Patricia Klaas⁴  Robyn M. Busch⁵  Siddharth Srivastava⁶  Mustafa Sahin⁶  Thomas W. Frazier II⁷  Charis Eng⁸  Antonio Y. Hardan⁹ 

[1] Center for Neurological Restoration, Neurological Institute, Cleveland Clinic, Cleveland, OH, USA;Center for Neurological Restoration, Neurological Institute, Cleveland Clinic, Cleveland, OH, USA;Department of Quantitative Health Sciences, Lerner Research Institute, Cleveland Clinic, Cleveland, OH, USA;Department of Human Genetics, University of California Los Angeles, Los Angeles, CA, USA;Department of Neurology, Neurological Institute, Cleveland Clinic, Cleveland, OH, USA;Department of Neurology, Neurological Institute, Cleveland Clinic, Cleveland, OH, USA;Epilepsy Center, Neurological Institute, Cleveland Clinic, Cleveland, OH, USA;Genomic Medicine Institute, Lerner Research Institute, Cleveland Clinic, Cleveland, OH, USA;Department of Neurology, Rosamund Stone Zander Translational Neuroscience Center, Boston Children’s Hospital, Harvard Medical School, Boston, MA, USA;Genomic Medicine Institute, Lerner Research Institute, Cleveland Clinic, Cleveland, OH, USA;Department of Psychology, John Carroll University, University Heights, OH, USA;Genomic Medicine Institute, Lerner Research Institute, Cleveland Clinic, Cleveland, OH, USA;Taussig Cancer Institute, Cleveland Clinic, Cleveland, OH, USA;Department of Genetics and Genome Sciences, Case Western Reserve University, Cleveland, OH, USA;Psychiatry and Behavioral Sciences, Stanford University Medical Center, Stanford, CA, USA;

关键词: PTEN;    PTEN hamartoma tumor syndrome;    Autism spectrum disorder;    Cognition;    Behavior;    Reliable change indices;    Standardized regression-based change scores;   

DOI  :  10.1186/s11689-022-09468-4

 received in 2022-02-28, accepted in 2022-11-18,  发布年份 2022

来源: Springer

【 授权许可】

CC BY   
© The Author(s) 2022

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Fig. 6