18F-JK-PSMA-7 PET/CT for staging intermediate- or high-risk prostate cancer patients before radical prostatectomy: a pilot study

European Journal of Hybrid Imaging

Original Article

Irina Vierasu¹  Nicola Trotta¹  Serge Goldman²  Gaetan Van Simaeys²  Simon Lacroix²  Guy Bormans³  Thierry Quackels⁴  Thierry Roumeguère⁴  Simone Albisinni⁴ 

[1] Nuclear Medicine Department & PET/Biomedical Cyclotron Unit, Hôpital Erasme, Université libre de Bruxelles (ULB), Route de Lennik 808, 1070, Brussels, Belgium;Nuclear Medicine Department & PET/Biomedical Cyclotron Unit, Hôpital Erasme, Université libre de Bruxelles (ULB), Route de Lennik 808, 1070, Brussels, Belgium;Center for Microscopy and Molecular Imaging (CMMI), Université libre de Bruxelles (ULB), Charleroi, Gosselies, Belgium;Radiopharmaceutical Recherche, KU Leuven, Leuven, Belgium;Urology Department, Cliniques Universitaires de Bruxelles, HUB, Hôpital Erasme, Université libre de Bruxelles (ULB), Brussels, Belgium;

关键词: High-risk prostate cancer;    Intermediate-risk prostate cancer;    Initial staging;    Pre-surgery F-JK-PSMA7 PET/CT;    Post-surgery F-JK-PSMA7 PET/CT;   

DOI  :  10.1186/s41824-022-00161-2

 received in 2022-10-31, accepted in 2022-12-28,  发布年份 2022

来源: Springer

【 摘 要 】

BackgroundPositron emission tomography/computed tomography (PET/CT) using radiotracers that bind to the prostate-specific membrane antigen (PSMA) is mainly used in biochemical recurring prostate cancer. The aim of our study was to assess the usefulness of 18F-JK-PSMA-7 PET/CT for local and nodal staging in patients with intermediate- and high-risk prostate cancer (PCa) prior to radical prostatectomy, as compared to conventional imaging techniques.MethodsWe enrolled a total of 10 patients with intermediate- and high-risk PCa diagnosed by multiparametric-MRI followed by systematic and targeted biopsies, eligible for radical prostatectomy with extended lymph node dissection. Clinical team was blind to the results of the pre-surgery 18F-JK-PSMA-7 PET/CT at times of clinical decision and surgery. One month post-surgery, 18F-JK-PSMA-7 PET/CT was repeated and the results of both scans were unblinded. A third 18F-JK-PSMA-7 PET/CT could be acquired at a later time point depending on PSA progression.ResultsAll pre-surgery 18F-JK-PSMA-7 PET/CT was positive in the prostatic region, while MRI was negative in the prostate in one patient. We also detected positive pelvic lymph nodes in two patients (one high-risk, one intermediate-risk PCa) on pre-surgery and post-surgery 18F-JK-PSMA-7 PET/CT. No positive pelvic lymph nodes were reported on pre-surgical CT and MRI. 18F-JK-PSMA-7 PET/CT detected bladder involvement in one patient and seminal vesicles involvement in two patients; this malignant extension was undetected by the conventional imaging techniques. SUVmax in prostate lesions had an average value of 11.51 (range 6.90–21.49). SUVmean in prostate lesions had an average value of 7.59 (range 5.26–14.02).ConclusionThis pilot study indicates that pre-surgery 18F-JK-PSMA-7 PET/CT provides valuable information in intermediate- and high-risk PCa, for surgery planning with curative intent.

【 授权许可】

CC BY   
© The Author(s) 2023

【 图 表 】

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Fig. 5