Association between basal septal hypertrophy and left ventricular geometry in a community population

BMC Cardiovascular Disorders

Research

Chonghui Wang¹  Min Li¹  Litong Qi²  Ying Yang²  Wei Ma²  Baowei Zhang²  Lan Gao²  Yan Zhang³  Yong Huo³ 

[1] Division of Cardiology, Department of Cardiovascular Disease, Peking University First Hospital, Dahongluochang Street, Xicheng District, 100034, Beijing, China;Division of Cardiology, Department of Cardiovascular Disease, Peking University First Hospital, Dahongluochang Street, Xicheng District, 100034, Beijing, China;Echocardiography Core Lab, Institute of Cardiovascular Disease at Peking University First Hospital, Beijing, China;Division of Cardiology, Department of Cardiovascular Disease, Peking University First Hospital, Dahongluochang Street, Xicheng District, 100034, Beijing, China;Key Laboratory of Molecular Cardiovascular Sciences (Peking University), Ministry of Education, Beijing, China;

关键词: Basal septal hypertrophy;    Left ventricular geometry;    Echocardiography;   

DOI  :  10.1186/s12872-022-03004-x

 received in 2022-01-05, accepted in 2022-12-12,  发布年份 2022

来源: Springer

【 摘 要 】

BackgroundLeft ventricular (LV) geometry is closely associated with cardiovascular disease; however, few studies have evaluated the relationship between basal septal hypertrophy (BSH) and LV geometry. In this study, we examined the relationship between BSH and LV geometry in a Beijing community population.MethodsThe clinical and echocardiographic data of 1032 participants from a community in Beijing were analyzed. BSH was defined as a basal interventricular septal thickness ≥ 14 mm and a basal septal thickness/mid-septal thickness ≥ 1.3. On the basis of their echocardiographic characteristics, patients were described as having a normal geometry, concentric remodeling, concentric hypertrophy, or eccentric hypertrophy. Multivariable logistic regression was used to analyze the relationship between BSH, LV mass index (LVMI), and relative wall thickness (RWT).ResultsThe prevalence of BSH was 7.4% (95% confidence interval [CI] 5.8–9.0%). Basal and middle interventricular septal thickness, LV posterior wall thickness, and RWT were greater, while LVMI and LV end-diastolic dimension were lower in the BSH group than in the non-BSH group (p < 0.05). The BSH group accounted for the highest proportion of patients with concentric remodeling. A multivariable regression analysis showed that BSH increased by 3.99-times (odds ratio [OR] 3.99, 95% CI 2.05–7.78, p < 0.01) when RWT was > 0.42, but not when LVMI increased (OR 0.16, 95% CI 0.02–1.19, p = 0.07). There were no interactions between BSH and age, body mass index, sex, diabetes mellitus, coronary heart disease, stroke, and smoking in relation to an RWT > 0.42.ConclusionBSH was independently associated with an RWT > 0.42.

【 授权许可】

CC BY   
© The Author(s) 2022

【 图 表 】

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