Resistin-like molecules: a marker, mediator and therapeutic target for multiple diseases

Cell Communication and Signaling

Review

Neng Zhu¹  Junlan Tan²  Feiying Wang²  Aiguo Dai³  Yun Qiu⁴  Li Qin⁵  Yaning Shi⁶ 

[1] Department of Urology, The First Hospital of Hunan University of Chinese Medicine, 410021, Changsha, Hunan, China;Hunan Provincial Key Laboratory of Vascular Biology and Translational Medicine, 410208, Changsha, Hunan, China;Hunan Provincial Key Laboratory of Vascular Biology and Translational Medicine, 410208, Changsha, Hunan, China;Department of Respiratory Diseases, Medical School, Hunan University of Chinese Medicine, 410208, Changsha, Hunan, China;Department of Respiratory Medicine, First Affiliated Hospital, Hunan University of Chinese Medicine, 410021, Changsha, Hunan, China;Laboratory of Stem Cell Regulation with Chinese Medicine and its Application, Hunan University of Chinese Medicine, 410208, Changsha, Hunan, China;Laboratory of Stem Cell Regulation with Chinese Medicine and its Application, Hunan University of Chinese Medicine, 410208, Changsha, Hunan, China;Hunan Provincial Key Laboratory of Vascular Biology and Translational Medicine, 410208, Changsha, Hunan, China;Laboratory of Stem Cell Regulation with Chinese Medicine and its Application, Hunan University of Chinese Medicine, 410208, Changsha, Hunan, China;Science and Technology Innovation Center, Hunan University of Chinese Medicine, 410208, Changsha, Hunan, China;

关键词: Resistin-like molecules;    Inflammation;    Proliferation;    Parasite;    Lung disease;   

DOI  :  10.1186/s12964-022-01032-w

 received in 2022-09-15, accepted in 2022-12-27,  发布年份 2022

来源: Springer

【 摘 要 】

Resistin-like molecules (RELMs) are highly cysteine-rich proteins, including RELMα, RELMβ, Resistin, and RELMγ. However, RELMs exhibit significant differences in structure, distribution, and function. The expression of RELMs is regulated by various signaling molecules, such as IL-4, IL-13, and their receptors. In addition, RELMs can mediate numerous signaling pathways, including HMGB1/RAGE, IL-4/IL-4Rα, PI3K/Akt/mTOR signaling pathways, and so on. RELMs proteins are involved in wide range of physiological and pathological processes, including inflammatory response, cell proliferation, glucose metabolism, barrier defense, etc., and participate in the progression of numerous diseases such as lung diseases, intestinal diseases, cardiovascular diseases, and cancers. Meanwhile, RELMs can serve as biomarkers, risk predictors, and therapeutic targets for these diseases. An in-depth understanding of the role of RELMs may provide novel targets or strategies for the treatment and prevention of related diseases.81_RffzerTWwVqeCYH81tPVideo abstract

【 授权许可】

CC BY   
© The Author(s) 2023

【 图 表 】

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