Biochemical and molecular biomarkers: unraveling their role in gestational diabetes mellitus

Diabetology & Metabolic Syndrome

Review

Masoumeh Karami¹  Seyedeh Zahra Shahrokhi¹  Seyyed Hossein Mousavi²  Mohammad Rafiee³  Reza Heidari⁴ 

[1] Department of Biochemistry, School of Medicine, AJA University of Medical Sciences, Tehran, Iran;Department of Cardiology, School of Medicine, AJA University of Medical Sciences, Tehran, Iran;Department of Medical Laboratory Sciences, School of Paramedical Sciences, Zanjan University of Medical Sciences, Zanjan, Iran;Medical Biotechnology Research Center, AJA University of Medical Sciences, Tehran, Iran;Research Center for Cancer Screening and Epidemiology, AJA University of Medical Sciences, Tehran, Iran;

关键词: β-cell dysfunction;    Biomarker;    Gestational diabetes mellitus;    Insulin resistance;    MicroRNA;   

DOI  :  10.1186/s13098-023-00980-8

 received in 2022-10-14, accepted in 2023-01-05,  发布年份 2023

来源: Springer

【 摘 要 】

Gestational diabetes mellitus (GDM) is the most prevalent metabolic disorder during pregnancy, causing short- and long-term complications for both mother and baby. GDM is a multifactorial disease, and it may be affected by interactions between genetic, epigenetic, and environmental factors. However, the exact etiology is poorly understood. Despite the high prevalence of GDM, there is still debate regarding the optimal time for screening, the diagnostic threshold to apply, and the best strategies for treatment. Identifying effective strategies for therapeutic purposes as well as accurate biomarkers for prognostic and diagnostic purposes will reduce the GDM incidence and improve its management. In recent years, new biochemical and molecular biomarkers such as microRNAs, single-nucleotide polymorphisms, and DNA methylation have received great interest in the diagnosis of GDM. In this review, we discuss current and future diagnostic approaches for the detection of GDM and evaluate lifestyle and pharmacological strategies for GDM prevention.

【 授权许可】

CC BY   
© The Author(s) 2023

【 图 表 】

41116_2022_35_Article_IEq159.gif

41116_2022_35_Article_IEq153.gif