期刊论文详细信息
Respiratory Research
Nasal TSLP and periostin in infants with severe bronchiolitis and risk of asthma at 4 years of age
Research
Cristina Calvo1  Beatriz Sastre2  Victoria Del Pozo3  José Manuel Rodrigo-Muñoz3  Maria Arroyas4  Patricia Alonso4  Maite Beato4  Maria Luz Garcia-Garcia5  Inmaculada Casas6 
[1] CIBER de Enfermedades Infecciosas (CIBERINFEC), Madrid, Spain;Translational Research Network in Pediatric Infectious Diseases (RITIP), Madrid, Spain;Pediatric Infectious Diseases Department, Hospital Universitario La Paz, Madrid, Spain;Fundación IdiPaz, Madrid, Spain;TEDDY Network (European Network of Excellence for Pediatric Clinical Research), Madrid, Spain;Department of Immunology, IIS-Fundación Jiménez Díaz, Madrid, Spain;Department of Immunology, IIS-Fundación Jiménez Díaz, Madrid, Spain;CIBER de Enfermedades Respiratorias (CIBERES), Madrid, Spain;Pediatrics Department, Hospital Universitario Severo Ochoa, Avenida Orellana s/n, 28911, Leganés, Madrid, Spain;Fundación para la Investigación Biomédica, Hospital Universitario Puerta de Hierro, Majadahonda, Spain;Pediatrics Department, Hospital Universitario Severo Ochoa, Avenida Orellana s/n, 28911, Leganés, Madrid, Spain;Fundación para la Investigación Biomédica, Hospital Universitario Puerta de Hierro, Majadahonda, Spain;CIBER de Enfermedades Infecciosas (CIBERINFEC), Madrid, Spain;Translational Research Network in Pediatric Infectious Diseases (RITIP), Madrid, Spain;Respiratory Virus and Influenza Unit, National Microbiology Centre (ISCIII), Madrid, Spain;
关键词: Bronchiolitis;    Asthma;    Recurrent wheezing;    Periostin;    Thymic stromal lymphopoietin (TSLP);    Respiratory syncytial virus (RSV);    Rhinovirus (HRV);   
DOI  :  10.1186/s12931-023-02323-7
 received in 2022-09-13, accepted in 2023-01-11,  发布年份 2023
来源: Springer
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【 摘 要 】

BackgroundSevere bronchiolitis is often associated with subsequent respiratory morbidity, mainly recurrent wheezing and asthma. However, the underlying immune mechanisms remain unclear. The main goal of this study was to investigate the association of nasal detection of periostin and thymic stromal lymphopoietin (TSLP) during severe bronchiolitis with the development of asthma at 4 years of age.MethodsObservational, longitudinal, post-bronchiolitis, hospital-based, follow-up study. Children hospitalized for bronchiolitis between October/2013 and July/2017, currently aged 4 years, included in a previous study to investigate the nasal airway secretion of TSLP and periostin during bronchiolitis, were included. Parents were contacted by telephone, and were invited to a clinical interview based on a structured questionnaire to obtain information on the respiratory evolution. The ISAAC questionnaire for asthma symptoms for 6–7-year-old children, was also employed.ResultsA total of 248 children were included (median age 4.4 years). The mean age at admission for bronchiolitis was 3.1 (IQR: 1.5–6.5) months. Overall, 21% had ever been diagnosed with asthma and 37% had wheezed in the last 12 months. Measurable nasal TSLP was detected at admission in 27(11%) cases and periostin in 157(63%). The detection of nasal TSLP was associated with the subsequent prescription of maintenance asthma treatment (p = 0.04), montelukast (p = 0.01), and the combination montelukast/inhaled glucocorticosteroids (p = 0.03). Admissions for asthma tended to be more frequent in children with TSLP detection (p = 0.07). In the multivariate analysis, adjusting for potential confounders, the detection of TSLP remained independently associated with chronic asthma treatment prescription (aOR:2.724; CI 1.051–7.063, p:0.04) and with current asthma (aOR:3.41; CI 1.20–9.66, p:0.02).Nasal detection of periostin was associated with lower frequency of ever use of short-acting beta2-agonists (SABA) (p = 0.04), lower prevalence of current asthma (p = 0.02), less prescription of maintenance asthma treatment in the past 12 months (p = 0.02, respectively). In the multivariate analysis, periostin was associated with lower risk of asthma at 4 years, independently of the atopic status (aOR:0.511 CI 95% 0.284–0.918, p:0.025).ConclusionsOur results show a positive correlation between nasal TSLP detection in severe bronchiolitis and the presence of current asthma, prescription of asthma maintenance treatment and respiratory admissions up to the age of 4 years. By contrast, we found a protective association between nasal periostin detection and current asthma at 4 years, ever diagnosis of asthma, maintenance asthma treatment prescription, and respiratory admissions.

【 授权许可】

CC BY   
© The Author(s) 2023

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Fig. 5

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