Trends in the utilization of medicines sold in the private sector post- registration in South Africa and the implications for similar countries

BMC Public Health

Research

Moliehi Matlala¹  Ntobeko Magnate Mpanza¹  Mothobi Godfrey Keele²  Brian Godman³ 

[1] School of Pharmacy, Sefako Makgatho Health Sciences University, Pretoria, South Africa;School of Pharmacy, Sefako Makgatho Health Sciences University, Pretoria, South Africa;Department of Pharmacy and Pharmacology, University of the Witwatersrand, Johannesburgh, South Africa;School of Pharmacy, Sefako Makgatho Health Sciences University, Pretoria, South Africa;Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, G4 0RE, Glasgow, UK;Centre of Medical and Bio-Allied Health Sciences Research (CMBHSR), Ajman University, Ajman, United Arab Emirates;

关键词: Dispensed medicines;    Marketing authorisation;    Private sector;    Mental Health;    Retail pharmacy;    Multiple sourced medicines;    Single Exit Price;    South Africa;    SAHPRA;   

DOI  :  10.1186/s12889-023-15021-2

 received in 2022-09-08, accepted in 2023-01-10,  发布年份 2023

来源: Springer

【 摘 要 】

BackgroundRegulatory authorities register medicines for patients to access them within a reasonable period of time. There is a paucity of available data regarding the extent to which registered medicines reach the public after market authorisation is granted by the South African Health Products Regulatory Authority (SAHPRA). This is important since time spent by SAHPRA assessing medicines that are subsequently not launched onto the South African market means time wasted, which could be spent on assessing new medicines that address an unmet need in the country. Consequently, we initially analysed the time taken for registered medicines to reach patients and the relationship between medicines registered at SAHPRA and those subsequently dispensed in private pharmacies. The extent of registration of multiple sourced versus new patented medicines was also explored.MethodsA retrospective, descriptive and quantitative investigation was conducted for medicines registered between 2014 and 2019. Registered and dispensed medicines were compared to establish accessibility post registration. Data sources included SAHPRA and IQVIA datasets. Microsoft Excel and SAS were used for data storage, analysis, and computation of descriptive statistical analysis.ResultsOf (N = 2175) registered medicines, only 358 (16.5%; 95% CI 15.0%—18.1%) were dispensed to patients, and out of 1735 medicines registered between 2015 and 2019, only 57 (3.3%; 95% CI 2.5%—4.2%) were dispensed during the study period. Medicines acting on the central nervous system were registered and dispensed the most at 21.0% and 18.0%, respectively, whereas antineoplastic and immunomodulation agents were registered and dispensed only 11% and 5%, respectively. A concern was that only 13.0% of registered medicines were originators, with most either as generics, including branded generics, or pseudo-generics.ConclusionRegulatory measures should be implemented to ensure increased medicine access post-registration for new originators, especially for priority disease areas that benefit patients. Mental health diseases and improved access to oncology medicines require special attention and further investigation in South Africa.

【 授权许可】

CC BY   
© The Author(s) 2023

【 图 表 】

Fig. 1