T1ρ, T2 and T2* mapping of lumbar intervertebral disc degeneration: a comparison study

BMC Musculoskeletal Disorders

Research

Quanlin Li¹  Cong Sun²  Tao Gong³  Xin Chen³  Xinjuan Zhang³  Li Yang⁴ 

[1] Department of Radiology, Affiliated Hospital of Shandong University of Traditional Chinese Medicine, 250012, Jinan, Shandong, China;Department of Radiology, Beijing Hospital, National Center of Gerontology, No. 1 Da-Hua Road, Dong Dan, 100730, Beijing, China;Department of Radiology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, 250021, Jinan, Shandong, China;Department of Radiology, Shanghai Institute of Medical Imaging, Zhongshan Hospital, Fudan University, 200032, Shanghai, People’s Republic of China;

关键词: T1ρ mapping;    T2 mapping;    T2* mapping;    Lumbar intervertebral disc;    Degeneration;   

DOI  :  10.1186/s12891-022-06040-y

 received in 2022-08-15, accepted in 2022-11-29,  发布年份 2022

来源: Springer

【 摘 要 】

BackgroundEarly and accurate assessment of lumbar intervertebral disc degeneration (IVDD) is very important to therapeutic strategy. This study aims to correlate and compare the performances of T1ρ, T2 and T2* mapping for Pfirrmann grades and morphologic changes in the IVDD.MethodsThis prospective study included 39 subjects with 195 lumbar discs. T1ρ, T2 and T2* mapping were performed, and T1ρ, T2 and T2* values of nucleus pulposus (NP), and anterior and posterior annulus fibrosus were measured. IVDD was assessed with Pfirrmann grading and morphologic changes (normal, bulging, herniation and annular fissure). The performances of T1ρ, T2 and T2* relaxation times were compared for detecting early (Pfirrmann grade II-III) and advanced degeneration (Pfirrmann grade IV–V), as well as for morphologic changes.ResultsT2 relaxation times was strongly corelated with T1ρ and T2* relaxation times. Areas under the curves (AUCs) of T1ρ, T2 and T2* relaxation times of NP were 0.70, 0.87 and 0.80 for early degeneration, and 0.91, 0.95 and 0.82 for advanced degeneration, respectively. AUCs of T1ρ, T2 and T2* relaxation times of NP were 0.78, 0.83 and 0.64 for bulging discs, 0.87, 0.89 and 0.69 for herniated discs, and 0.79, 0.82 and 0.69 for annular tearing, respectively. The AUC of T2 relaxation time was significantly higher than those of T1ρ relaxation times (both P < 0.01) for early IVDD, and the AUCs of T1ρ and T2 relaxation times for assessing advanced degeneration and morphologic changes were similar (P > 0.05) but significantly higher than that of T2*relaxation time (P < 0.01).ConclusionsT2 mapping performed better than T1ρ mapping for the detection of early IVDD. T1ρ and T2 mapping performed similarly but better than T2* mapping for advanced degeneration and morphologic changes of IVDD.

【 授权许可】

CC BY   
© The Author(s) 2022

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