Insights into the tumor microenvironment of B cell lymphoma

Journal of Experimental & Clinical Cancer Research

Review

Patrizia Mondello¹  Stephen M. Ansell¹  Wern Lynn Ng¹ 

[1] Division of Hematology, Mayo Clinic, 200 1st St SW, 55905, Rochester, MN, USA;

关键词: Tumor microenvironment;    B-cell lymphoma;    T cells;    T follicular helper cells;    T regulatory cells;    Tumor-associated macrophages;    Myeloid-derived suppressor cells;    Cancer-associated fibroblasts;   

DOI  :  10.1186/s13046-022-02579-9

 received in 2022-10-28, accepted in 2022-12-20,  发布年份 2022

来源: Springer

【 摘 要 】

The standard therapies in lymphoma have predominantly focused on targeting tumor cells with less of a focus on the tumor microenvironment (TME), which plays a critical role in favoring tumor growth and survival. Such an approach may result in increasingly refractory disease with progressively reduced responses to subsequent treatments. To overcome this hurdle, targeting the TME has emerged as a new therapeutic strategy. The TME consists of T and B lymphocytes, tumor-associated macrophages (TAMs), myeloid-derived suppressor cells (MDSCs), cancer-associated fibroblasts (CAFs), and other components. Understanding the TME can lead to a comprehensive approach to managing lymphoma, resulting in therapeutic strategies that target not only cancer cells, but also the supportive environment and thereby ultimately improve survival of lymphoma patients. Here, we review the normal function of different components of the TME, the impact of their aberrant behavior in B cell lymphoma and the current TME-direct therapeutic avenues.

【 授权许可】

CC BY   
© The Author(s) 2022

【 图 表 】

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