Effects of vitamin D supplementation in endometriosis: a systematic review

Reproductive Biology and Endocrinology

Review

Ioannis G. Lempesis¹  Nicolas Samartzis²  Ioannis Dedes³  Julian Matthias Metzler³  Patrick Imesch³  Dimitrios Rafail Kalaitzopoulos⁴  Angelos Daniilidis⁵  Konstantinos Nirgianakis⁶  Sofia Makieva⁷  Brigitte Leeners⁷ 

[1] College of Medical and Dental Sciences, Institute of Metabolism and Systems Research (IMSR), University of Birmingham, Birmingham, UK;Centre for Endocrinology, Diabetes and Metabolism (CEDAM), Birmingham Health Partners, Birmingham, UK;Department of Human Biology, School of Nutrition and Translational Research in Metabolism (NUTRIM), Maastricht University, Maastricht, the Netherlands;Department of Gynecology and Obstetrics, Cantonal Hospital Schaffhausen, Geissbergstrasse 81, 8208, Schaffhausen, Switzerland;Department of Gynecology, University Hospital Zurich, Frauenklinikstr. 10, 8091, Zurich, CH, Switzerland;Department of Gynecology, University Hospital Zurich, Frauenklinikstr. 10, 8091, Zurich, CH, Switzerland;Division of Reproductive Endocrinology, University Hospital Zurich, Frauenklinikstr. 10, 8091, Zurich, CH, Switzerland;Department of Obstetrics and Gynecology, 2Nd University, Hippokratio General Hospital, Aristotle University of Thessaloniki, Thessaloniki, Greece;Department of Obstetrics and Gynecology, University Hospital and University of Bern, Friedbühlstrasse 19, 3010, Bern, Switzerland;Division of Reproductive Endocrinology, University Hospital Zurich, Frauenklinikstr. 10, 8091, Zurich, CH, Switzerland;

关键词: Endometriosis;    Vitamin D;    1,25(OH)2D;    25(OH)D;    25(ΟΗ)D3;    Supplementation;   

DOI  :  10.1186/s12958-022-01051-9

 received in 2022-05-25, accepted in 2022-12-18,  发布年份 2022

来源: Springer

【 摘 要 】

BackgroundThere is a growing body of human, animal and in vitro studies on vitamin D (vit D) substitution in endometriosis. The aim of this systematic review is to critically appraise and qualitatively synthesize the results of the available studies that examine the supplementation of vit D for endometriosis treatment.MethodsA systematic search of the literature was conducted in four electronic databases (Medline, Cochrane, Scopus, Embase) and grey literature for original research articles on humans, animals and in vitro models published in any language.ResultsFour human studies, four animal studies and four in vitro studies were included. Quantitative synthesis of human studies showed no significant effect of vit D intake for dysmenorrhea (2 studies, 44 vit D vs 44 placebo, mean -0.71, 95% CI -1.94, 0.51) and non-cyclic pelvic pain (2 studies, 42 vit D vs 38 placebo, mean 0.34, 95% CI -0.02, 0.71). Regarding reproductive outcomes in women with endometriosis after in vitro fertilization, the only available study showed no differences between women taking vit D and women taking placebo. Three of the four included animal studies showed regression of endometriotic implants when treated with vit D. The in vitro studies demonstrated that vit D decreases invasion and proliferation of endometriotic lesions without affecting apoptosis.ConclusionsAlthough in vitro and animal studies suggest regression of the endometriotic implants and decrease of invasion and proliferation after vit D supplementation, this was not reflected in the results of the meta-analysis, which showed no benefit of vit D supplementation in patients with endometriosis and dysmenorrhea or non-cyclic pelvic pain as well as on the outcome of IVF treatment. However, given the heterogeneity and the diversity of the available studies, more research is required to shed light on the role of vit D supplementation in women with endometriosis.

【 授权许可】

CC BY   
© The Author(s) 2022

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