Analysis of macular blood flow changes in thyroid associated ophthalmopathy

BMC Ophthalmology

Research

Zhaode Zhang¹  Jinfeng Zhang¹  Lingli Lin¹  Xiaohan Zhang¹  Jinhui Dai²  Wangyuan Liu² 

[1] Department of Ophthalmology, Ningde Municipal Hospital of Ningde Normal University, No.13 Mindong East Road, Ningde, Fujian, China;Department of Ophthalmology, Zhongshan Hospital, Fudan University, No.180 Fenglin Road, Shanghai, China;

关键词: Thyroid-associated ophthalmopathy;    Vessel density;    Foveal avascular zone;    Optical coherence tomography angiography;   

DOI  :  10.1186/s12886-022-02716-0

 received in 2021-11-11, accepted in 2022-11-28,  发布年份 2022

来源: Springer

【 摘 要 】

BackgroundTo evaluate the changes in macular superficial retinal vessel density and their relation with visual acuity in thyroid-associated ophthalmopathy (TAO) patients with different severity.MethodsThis cross-sectional observational study included 70 TAO patients and 70 healthy controls. Only data from the right eyes were analyzed. TAO patients were divided into 7 subgroups according to the NOSPECS score. Foveal avascular zone (FAZ), vascular density (VD), and perfusion density (PD) of macular 1 mm diameter and 6 mm diameter areas were measured by optical coherence tomography angiography (OCTA).ResultsIn TAO patients, significant increases were found in macular and foveal vascular densities (FVD) and perfusion densities (FPD) while a significant decrease was found in the FAZ area when compared with the control group (p < 0.05). Spearman correlation analysis and multiple linear regression analysis showed that TAO severity grade was negatively correlated with FVD (β = -1.150, p = 0.032), FPD (β = -0.024, p = 0.042), MVD (β = -0.583, p = 0.020) and MPD (β = -0.011, p = 0.010). Clinical activity score (CAS) score showed positive correlation with FVD (β = 0.794, p = 0.035) and FPD(β = 0.017, p = 0.041). FVD (β = -0.009, p = 0.033), MVD(β = -0.034, p < 0.001), FPD(β = -0.416, p = 0.039) and MPD(β = -2.428, p < 0.001) all showed negative correlation with best corrected visual acuity (BCVA).ConclusionsThere was an overall increase in superficial macular blood flow in TAO patients compared with healthy controls and the blood flow decreased as TAO got worse. Superficial macular flow density was negatively correlated with BCVA.

【 授权许可】

CC BY   
© The Author(s) 2022

【 图 表 】

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