Laparoscopic versus open hepatectomy for intrahepatic cholangiocarcinoma in patients aged 60 and older: a retrospective cohort study

World Journal of Surgical Oncology

Research

Xiaolei Chen¹  Wei Wang²  Jianlei Wang³  Bin Jin⁴  Gang Du⁴  Tong Xia⁵  Delin Ma⁵  Zhaochen Jiang⁵ 

[1] Center for Reproductive Medicine, Shandong University, 157 Jingliu Road, 250000, Jinan, Shandong, China;Department of Operative Surgery, Integration and Practice Center, Cheeloo College Department of Medicine, Shandong University, 44 Wenhuaxi Road, 250000, Jinan, Shandong, China;Department of Operative Surgery, Integration and Practice Center, Cheeloo College Department of Medicine, Shandong University, 44 Wenhuaxi Road, 250000, Jinan, Shandong, China;Department of Organ Transplantation, Qilu Hospital of Shandong University, Cheeloo College of Medicine, 107 Wenhuaxi Road, 250000, Jinan, Shandong, China;Department of Organ Transplantation, Qilu Hospital of Shandong University, 107 Wenhuaxi Road, 250000, Jinan, Shandong, China;Department of Organ Transplantation, Qilu Hospital of Shandong University, Cheeloo College of Medicine, 107 Wenhuaxi Road, 250000, Jinan, Shandong, China;

关键词: Population aged 60 and older;    Intrahepatic cholangiocarcinoma;    Laparoscopic hepatectomy;    Open hepatectomy;    Prognosis;   

DOI  :  10.1186/s12957-022-02870-1

 received in 2022-06-28, accepted in 2022-12-04,  发布年份 2022

来源: Springer

【 摘 要 】

Objective laparoscopic surgical excision is the recommended treatment for liver cancers, yet its benefits in patients aged 60 and older remain poorly understood. Thus, this study evaluated the feasibility, safety, and clinical outcomes of laparoscopic hepatectomy for patients aged 60 and older with intrahepatic cholangiocarcinoma (ICC).MethodsAfter screening, 107 patients who underwent hepatectomy for ICC were enrolled and grouped into either laparoscopic (LH) or open hepatectomy (OH) groups. Baseline characteristics, pathological findings, and long-term outcomes were compared between the two groups. Independent prognostic factors for overall survival (OS) and disease-free survival (DFS) were identified using univariate and multivariate analyses.ResultsAmong baseline characteristics and pathological findings, only pre-operative albumin was higher in the LH group. The LH group had more favorable short-term outcomes such as incision length, level of postoperative total bilirubin, and length of postoperative stays than the OH group. The postoperative complication, lymph node dissection and R0 resection rate, and long-term outcomes including OS and DFS were not significantly different between the two groups. Cancer Antigen-19-9(CA-19-9) and pathological differentiation were independent prognostic factors for OS, whereas CA-19-9 and neutrophil count were independent prognostic factors for DFS.ConclusionLH is safe, reliable, and feasible for treatment of ICC patients aged 60 and older as it had better short-term clinical outcomes than OH and achieved long-term prognoses that were comparable to those of OH.

【 授权许可】

CC BY   
© The Author(s) 2022

【 图 表 】

Fig. 6

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