Sinonasal mucosal melanoma with smooth muscle differentiation: a potential pathological diagnostic pitfall

Diagnostic Pathology

Case Report

Wenfeng Xu¹  Yujuan Xu¹  Xianyun Li¹  Ying Chen¹  Hao Tang¹  Deyu Guo¹  Yutao He² 

[1] Department of Pathology, Guiqian International General Hospital, Guiyang, Guizhou Province, China;School of Public Health, Medical College, Wuhan University of Science and Technology, Wuhan, Hubei Province, China;

关键词: Sinonasal;    Melanoma;    Smooth muscle differentiation;    Pitfall;   

DOI  :  10.1186/s13000-022-01280-x

 received in 2022-09-22, accepted in 2022-12-19,  发布年份 2022

来源: Springer

【 摘 要 】

BackgroundSinonasal mucosal melanoma (SNMM) is a rare malignant melanoma originating from melanocytes derived from multipotent neural crest cells. Its incidence accounts for less than 1 % of all malignant melanomas, with five-year survival rate about 25 %. Occasionally, it is incredibly formidable to make a compelling diagnosis when malignant melanoma with other diverse differentiation.Case presentationHerein, we presented a 54-year-old male case of SNMM with smooth muscle differentiation, defined by histopathology and positive immunostaining for the smooth muscle specific markers of a-SMA, H-caldesmon, calponin and Desmin, as well as specific melanocyte markers of HMB-45, Melan-A, SOX10, and PNL2.ConclusionsMucosal melanoma with smooth muscle differentiation is remarkably infrequent, and reported only 4 cases to date. It would be a potential pathological diagnostic pitfall. It is important to understand this variation of malignant melanoma for avoiding misdiagnosis.

【 授权许可】

CC BY   
© The Author(s) 2022

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