Buprenorphine in rats: potent analgesic or trigger for fatal side effects?

Acta Veterinaria Scandinavica

Brief Communication

Janin Reifenrath¹  Nina Angrisani¹  Heidi Harting¹  Merle Kempfert²  Sarah Strauss³  Miriam Heider⁴  Friederike Weidemann⁵ 

[1] Hannover Medical School, Clinic for Orthopaedic Surgery, Carl-Neuberg-Straße 1, 30625, Hannover, Germany;Hannover Medical School, Clinic for Orthopaedic Surgery, Carl-Neuberg-Straße 1, 30625, Hannover, Germany;Deutsches Krebsforschungszentrum Stiftung des öffentlichen Rechts, Zentrum für Präklinische Forschung, Im Neuenheimer Feld 280, 69120, Heidelberg, Germany;Hannover Medical School, Department of Plastic, Aesthetic, Hand and Reconstructive Surgery, Carl-Neuberg-Straße 1, 30625, Hannover, Germany;Hannover Medical School, Institute for Laboratory Animal Science and Central Animal Facility, Carl-Neuberg-Straße 1, 30625, Hannover, Germany;Hannover Medical School, Trauma Department, Carl-Neuberg-Straße 1, 30625, Hannover, Germany;

关键词: Adverse effect;    Lewis;    Opioid;    Pain management;    Refinement;    Rodent;    Sprague Dawley;   

DOI  :  10.1186/s13028-022-00661-y

 received in 2022-07-11, accepted in 2022-12-07,  发布年份 2022

来源: Springer

【 摘 要 】

With ongoing animal welfare efforts, multimodal analgesia is often recommended to implement in study protocols. Buprenorphine with very potent analgesic effect is a standard opioid for the use in this context in rats. In this study, two rat strains (LEW/NHanZtm, n = 6 and Crl:CD(SD), n = 8) underwent orthopaedic surgery and received carprofen, buprenorphine and a local anaesthetic in a multimodal setup. Crl:CD(SD) rats showed severe side effects in the first 24 h after anaesthesia, predominantly manifesting in pica-behaviour and reaching humane endpoints in two of eight animals, while LEW/NHanZtm rats showed only slight depression in the first postoperative days. In the context of improving animal welfare in experimental studies, buprenorphine is highly recommended not to be used in male Crl:CD(SD) rats and should generally be used very carefully and only if required.

【 授权许可】

CC BY   
© The Author(s) 2022

【 图 表 】

Fig. 1

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