Myopericarditis following both BNT162b2 and NVX-CoV2373

Allergy, Asthma & Clinical Immunology

Case Report

Adrianna Le¹  Saima Ahmad²  Chino Yuson³  Pravin Hissaria⁴ 

[1] Royal Adelaide Hospital, Port Road Adelaide, 5000, Adelaide, SA, Australia;Royal Adelaide Hospital, Port Road Adelaide, 5000, Adelaide, SA, Australia;5000, Adelaide, SA, Australia;Royal Adelaide Hospital, Port Road Adelaide, 5000, Adelaide, SA, Australia;The University of Adelaide, Adelaide, Australia;Royal Adelaide Hospital, Port Road Adelaide, 5000, Adelaide, SA, Australia;The University of Adelaide, Adelaide, Australia;SA Pathology, Adelaide, Australia;

关键词: Myocarditis;    Pericarditis;    Myopericarditis;    COVID-19;    SARS-Cov-2;    Vaccination;    BNT162b2;    mRNA-1273;    NVX-CoV2373;   

DOI  :  10.1186/s13223-022-00750-7

 received in 2022-10-16, accepted in 2022-12-08,  发布年份 2022

来源: Springer

【 摘 要 】

BackgroundMyopericarditis is a well reported complication associated with SARS-Cov-2 (COVID-19) infection and vaccinations; particularly with mRNA vaccines (BNT162b2 and mRNA-1273), and in the young male population. The risk-to-benefit ratio in sequential vaccination dosing in young males is further clouded in the era of the omicron variant with its reported enhanced immune escape.Study designA case series of two cases of post vaccination myopericarditis following the NVX-CoV2373 after also developing myopericarditis with BNT162b2.ConclusionTo our knowledge, we are the first to describe post vaccination myopericarditis followingNVX-CoV2373 after also developing myopericarditis with BNT162b2. The similarities in presentation between the reactions of both platforms would suggest a similar pathogenesis, although the exact mechanism remains unknown. Further studies are necessary to identify these mechanisms, as well as to identify biomarkers that may identify vulnerable populations. On-going vigilance is necessary to identify those who may be at an increased risk of post-COVID vaccine myopericarditis.

【 授权许可】

CC BY   
© Crown 2022

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