In Silico functional and phylogenetic analyses of fungal immunomodulatory proteins of some edible mushrooms

AMB Express

Original Article

Aveek Samanta¹  Ayyagari Ramlal² 

[1] Department of Botany, Prabhat Kumar College, 721401, Contai, West Bengal, India;Department of Botany, University of Delhi, 110007, New Delhi, Delhi, India;School of Biological Sciences, Universiti Sains Malaysia (USM), 11800, Georgetown, Penang, Malaysia;

关键词: Mushrooms;    Traditional medicines;    Fungal immunomodulatory proteins (FIPs);    Motifs;    Bioactive peptides;    Diseases;   

DOI  :  10.1186/s13568-022-01503-w

 received in 2022-10-17, accepted in 2022-12-13,  发布年份 2022

来源: Springer

【 摘 要 】

Mushrooms are a well known source of many bioactive and nutritional compounds with immense applicability in both the pharmaceutical and food industries. They are widely used to cure various kinds of ailments in traditional medicines. They have a low amount of fats and cholesterol and possess a high number of proteins. Immunomodulators have the ability which can improve immunity and act as defensive agents against pathogens. One such class of immunomodulators is fungal immunomodulatory proteins (FIPs). FIPs have potential roles in the treatment of cancer, and immunostimulatory effects and show anti-tumor activities. In the current study, 19 FIPs from edible mushrooms have been used for comparison and analysis of the conserved motifs. Phylogenetic analysis was also carried out using the FIPs. The conserved motif analysis revealed that some of the motifs strongly supported their identity as FIPs while some are novel. The fungal immunomodulatory proteins are important and have many properties which can be used for treating ailments and diseases and this preliminary study can be used for the identification and functional characterization of the proposed novel motifs and in unraveling the potential roles of FIPs for developing newer drugs.

【 授权许可】

CC BY   
© The Author(s) 2022

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